edobacomab

{{Drugbox

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| verifiedrevid = 458638230

| type = mab

| mab_type = mab

| source = o

| target = endotoxin

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| routes_of_administration = Intravenous infusion

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| ChemSpiderID = none

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| CAS_number = 141410-98-2

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| UNII = 01L0MVY85E

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Edobacomab, codenamed E5, is a mouse monoclonal antibody that was investigated as a possible treatment for sepsis caused by Gram-negative bacterial infections.

{{cite journal | vauthors = Greenman RL, Schein RM, Martin MA, Wenzel RP, MacIntyre NR, Emmanuel G, Chmel H, Kohler RB, McCarthy M, Plouffe J | display-authors = 6 | title = A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group | journal = JAMA | volume = 266 | issue = 8 | pages = 1097–102 | date = August 1991 | pmid = 1865542 | doi = 10.1001/jama.266.8.1097 }}
{{cite journal | vauthors = Bone RC, Balk RA, Fein AM, Perl TM, Wenzel RP, Reines HD, Quenzer RW, Iberti TJ, Macintyre N, Schein RM | display-authors = 6 | title = A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group | journal = Critical Care Medicine | volume = 23 | issue = 6 | pages = 994–1006 | date = June 1995 | pmid = 7774238 | doi = 10.1097/00003246-199506000-00003 }}
{{cite journal | vauthors = Angus DC, Birmingham MC, Balk RA, Scannon PJ, Collins D, Kruse JA, Graham DR, Dedhia HV, Homann S, MacIntyre N | display-authors = 6 | title = E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators | journal = JAMA | volume = 283 | issue = 13 | pages = 1723–30 | date = April 2000 | pmid = 10755499 | doi = 10.1001/jama.283.13.1723 | doi-access = free }}

Further reading