encainide

{{short description|Chemical compound}}

{{Drugbox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 461093505

| IUPAC_name = 4-Methoxy-N-[2-(1-methyl-2-piperidin-1-ylethyl)phenyl]benzamide

| image = Encainide.svg

| tradename = Enkaid

| Drugs.com = {{drugs.com|CONS|encainide}}

| MedlinePlus = a605040

| pregnancy_AU =

| pregnancy_US =

| pregnancy_category =

| legal_AU =

| legal_UK =

| legal_US =

| legal_status = Withdrawn

| routes_of_administration =

| bioavailability =

| protein_bound =

| metabolism =

| elimination_half-life =

| excretion =

| CAS_number_Ref = {{cascite|correct|??}}

| CAS_number = 66778-36-7

| ATC_prefix = C01

| ATC_suffix = BC08

| ATC_supplemental =

| PubChem = 48041

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| DrugBank = DB01228

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 315838

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 43697

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = SY3J0147NB

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = D07894

| ChEBI_Ref = {{ebicite|correct|EBI}}

| ChEBI = 4788

| C=22 | H=28 | N=2 | O=2

| smiles = COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/C22H28N2O2/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25)

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = PJWPNDMDCLXCOM-UHFFFAOYSA-N

}}

Encainide (trade name Enkaid) is a class Ic antiarrhythmic agent. It is no longer used because of its frequent proarrhythmic side effects.{{cite journal | vauthors = Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, Arensberg D, Baker A, Friedman L, Greene HL | display-authors = 6 | title = Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial | journal = The New England Journal of Medicine | volume = 324 | issue = 12 | pages = 781–8 | date = March 1991 | pmid = 1900101 | doi = 10.1056/NEJM199103213241201 | doi-access = free }}