endothelin receptor type B

Endothelin receptor type B is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET₁, ET₂, and ET₃. A splice variant, named SVR, has been described; the sequence of the ETB-SVR receptor is identical to ETRB except for the intracellular C-terminal domain. While both splice variants bind ET₁, they exhibit different responses upon binding which suggests that they may be functionally distinct.{{cite web | title = Entrez Gene: EDNRB endothelin receptor type B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1910}}

In melanocytic cells the EDNRB gene is regulated by the microphthalmia-associated transcription factor. Mutations in either gene are links to Waardenburg syndrome.{{cite journal | vauthors = Sato-Jin K, Nishimura EK, Akasaka E, Huber W, Nakano H, Miller A, Du J, Wu M, Hanada K, Sawamura D, Fisher DE, Imokawa G | title = Epistatic connections between microphthalmia-associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders | journal = FASEB Journal | volume = 22 | issue = 4 | pages = 1155–68 | date = Apr 2008 | pmid = 18039926 | doi = 10.1096/fj.07-9080com | doi-access = free | s2cid = 14304386 }}{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell & Melanoma Research | volume = 21 | issue = 6 | pages = 665–76 | date = Dec 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x | doi-access = free }}

The multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene.{{cite journal | vauthors = Tanaka H, Moroi K, Iwai J, Takahashi H, Ohnuma N, Hori S, Takimoto M, Nishiyama M, Masaki T, Yanagisawa M, Sekiya S, Kimura S | title = Novel mutations of the endothelin B receptor gene in patients with Hirschsprung's disease and their characterization | journal = The Journal of Biological Chemistry | volume = 273 | issue = 18 | pages = 11378–83 | date = May 1998 | pmid = 9556633 | doi = 10.1074/jbc.273.18.11378 | doi-access = free }}

In horses, a mutation in the middle of the EDNRB gene, Ile118Lys, when homozygous, causes Lethal White Syndrome.{{cite journal | vauthors = Yang GC, Croaker D, Zhang AL, Manglick P, Cartmill T, Cass D | title = A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndrome (LWFS); a horse variant of Hirschsprung disease | journal = Human Molecular Genetics | volume = 7 | issue = 6 | pages = 1047–52 | date = Jun 1998 | pmid = 9580670 | doi = 10.1093/hmg/7.6.1047 | quote = AG mutation, which changed isoleucine to lysine in the predicted first transmembrane domain of the EDNRB protein. This was associated with LWFS when homozygous and with the overo phenotype when heterozygous. --> | doi-access = free }} In this mutation, a mismatch in the DNA replication causes lysine to be made instead of isoleucine. The resulting EDNRB protein is unable to fulfill its role in the development of the embryo, limiting the migration of the melanocyte and enteric neuron precursors. A single copy of the EDNRB mutation, the heterozygous state, produces an identifiable and completely benign spotted coat color called frame overo.{{cite journal | vauthors = Metallinos DL, Bowling AT, Rine J | title = A missense mutation in the endothelin-B receptor gene is associated with Lethal White Foal Syndrome: an equine version of Hirschsprung disease | journal = Mamm. Genome | volume = 9 | issue = 6 | pages = 426–31 | year = 1998 | pmid = 9585428 | doi = 10.1007/s003359900790| s2cid = 19536624 | quote = }}

Endothelin receptor type B has been shown to interact with Caveolin 1.{{cite journal | vauthors = Yamaguchi T, Murata Y, Fujiyoshi Y, Doi T | title = Regulated interaction of endothelin B receptor with caveolin-1 | journal = European Journal of Biochemistry | volume = 270 | issue = 8 | pages = 1816–27 | date = Apr 2003 | pmid = 12694195 | doi = 10.1046/j.1432-1033.2003.03544.x | doi-access = free }}

; Agonists

• IRL-1620{{cite journal | vauthors = Maguire JJ, Davenport AP | title = Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12 | journal = British Journal of Pharmacology | volume = 171 | issue = 24 | pages = 5555–72 | date = Dec 2014 | pmid = 25131455 | doi = 10.1111/bph.12874 | pmc=4290702}}

; Antagonists

• A-192,621
• BQ-788
• Bosentan (unselective ET_A / ET_B antagonist)

• Endothelin receptor

{{reflist|33em}}

{{refbegin|33em}}

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• {{cite journal | vauthors = Haendler B, Hechler U, Schleuning WD | title = Molecular cloning of human endothelin (ET) receptors ETA and ETB | journal = Journal of Cardiovascular Pharmacology | volume = 20 | pages = S1–4 | year = 1993 | issue = Suppl 12 | pmid = 1282938 | doi = 10.1097/00005344-199204002-00002 | s2cid = 37973815 | doi-access = free }}
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• {{cite journal | vauthors = Sakamoto A, Yanagisawa M, Sakurai T, Takuwa Y, Yanagisawa H, Masaki T | title = Cloning and functional expression of human cDNA for the ETB endothelin receptor | journal = Biochemical and Biophysical Research Communications | volume = 178 | issue = 2 | pages = 656–63 | date = Jul 1991 | pmid = 1713452 | doi = 10.1016/0006-291X(91)90158-4 }}
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• {{cite journal | vauthors = Baynash AG, Hosoda K, Giaid A, Richardson JA, Emoto N, Hammer RE, Yanagisawa M | title = Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons | journal = Cell | volume = 79 | issue = 7 | pages = 1277–85 | date = Dec 1994 | pmid = 8001160 | doi = 10.1016/0092-8674(94)90018-3 | s2cid = 32577813 }}
• {{cite journal | vauthors = Arai H, Nakao K, Takaya K, Hosoda K, Ogawa Y, Nakanishi S, Imura H | title = The human endothelin-B receptor gene. Structural organization and chromosomal assignment | journal = The Journal of Biological Chemistry | volume = 268 | issue = 5 | pages = 3463–70 | date = Feb 1993 | doi = 10.1016/S0021-9258(18)53717-0 | pmid = 8429023 | doi-access = free }}
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• {{cite journal | vauthors = Attié T, Till M, Pelet A, Amiel J, Edery P, Boutrand L, Munnich A, Lyonnet S | title = Mutation of the endothelin-receptor B gene in Waardenburg-Hirschsprung disease | journal = Human Molecular Genetics | volume = 4 | issue = 12 | pages = 2407–9 | date = Dec 1995 | pmid = 8634719 | doi = 10.1093/hmg/4.12.2407 }}
• {{cite journal | vauthors = Elshourbagy NA, Adamou JE, Gagnon AW, Wu HL, Pullen M, Nambi P | title = Molecular characterization of a novel human endothelin receptor splice variant | journal = The Journal of Biological Chemistry | volume = 271 | issue = 41 | pages = 25300–7 | date = Oct 1996 | pmid = 8810293 | doi = 10.1074/jbc.271.41.25300 | doi-access = free }}
• {{cite journal | vauthors = Kusafuka T, Wang Y, Puri P | title = Novel mutations of the endothelin-B receptor gene in isolated patients with Hirschsprung's disease | journal = Human Molecular Genetics | volume = 5 | issue = 3 | pages = 347–9 | date = Mar 1996 | pmid = 8852658 | doi = 10.1093/hmg/5.3.347 | doi-access = }}
• {{cite journal | vauthors = Auricchio A, Casari G, Staiano A, Ballabio A | title = Endothelin-B receptor mutations in patients with isolated Hirschsprung disease from a non-inbred population | journal = Human Molecular Genetics | volume = 5 | issue = 3 | pages = 351–4 | date = Mar 1996 | pmid = 8852659 | doi = 10.1093/hmg/5.3.351 | doi-access = free }}
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• {{cite journal | vauthors = Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, Lefkowitz RJ | title = Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity | journal = The Journal of Biological Chemistry | volume = 272 | issue = 28 | pages = 17734–43 | date = Jul 1997 | pmid = 9211925 | doi = 10.1074/jbc.272.28.17734 | doi-access = free }}
• {{cite journal | vauthors = Mazzuca MQ, Khalil RA | title = Vascular endothelin receptor type B: structure, function and dysregulation in vascular disease | journal = Biochemical Pharmacology | volume = 84 | issue = 2 | pages = 147–62 | date = Jul 2012 | pmid = 22484314 | doi = 10.1016/j.bcp.2012.03.020 | pmc = 3358417 }}
• {{cite journal | vauthors = Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ | title = Endothelin | journal = Pharmacological Reviews | volume = 68 | issue = 2 | pages = 357–418 | date = April 2016 | pmid = 26956245 | doi = 10.1124/pr.115.011833 | pmc=4815360}}

{{refend}}

• {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2265 | title = Endothelin Receptors: ET_B | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology }}

{{NLM content}}

{{G protein-coupled receptors}}

{{DEFAULTSORT:Endothelin Receptor Type B}}

Category:G protein-coupled receptors