ethanolamine ammonia-lyase
{{infobox enzyme
| Name = ethanolamine ammonia-lyase
| EC_number = 4.3.1.7
| CAS_number = 9054-69-7
| GO_code = 0008851
| image =
| width =
| caption =
}}
The enzyme ethanolamine ammonia-lyase (EC 4.3.1.7) catalyzes the chemical reaction
:ethanolamine acetaldehyde + NH3
This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is ethanolamine ammonia-lyase (acetaldehyde-forming). It is also called ethanolamine deaminase. It participates in glycerophospholipid metabolism. It employs one cofactor, adenosylcobalamin.
Structural studies
As of early 2011, several structures have been solved for this class of enzymes. The first structure solved was the active site containing EutB subunit of EAL from Listeria monocytogenes with the PDB accession code {{PDB link|2QEZ}}. Later, more structures have become available from Escherichia coli that include both EAL subunits bound to various ligands.
References
{{reflist|1}}
- {{cite journal | author = Bradbeer C | date = 1965 | title = The clostridial fermentations of choline and ethanolamine. 1 Preparation and properties of cell-free extracts | journal = J. Biol. Chem. | volume = 240 | pages = 4669–74 | pmid = 5846987 | issue = 12 | doi = 10.1016/S0021-9258(18)97007-9 | doi-access = free }}
- {{cite journal | author = Bradbeer C | date = 1965 | title = The clostridial fermentations of choline and ethanolamine. II Requirement for a cobamide coenzyme by an ethanolamine deaminase | journal = J. Biol. Chem. | volume = 240 | pages = 4675–81 | pmid = 5846988 | issue = 12 | doi = 10.1016/S0021-9258(18)97008-0 | doi-access = free }}
- {{cite journal |vauthors=Kaplan BH, Stadtman ER | date = 1968 | title = Ethanolamine deaminase, a cobamide coenzyme-dependent enzyme. I Purification, assay, and properties of the enzyme | journal = J. Biol. Chem. | volume = 243 | pages = 1787–93 | pmid = 4297225 | issue = 8 | doi = 10.1016/S0021-9258(18)93512-X | doi-access = free }}
{{Carbon-nitrogen lyases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
Category:Enzymes of known structure
{{enzyme-stub}}