fibrinogen alpha chain

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin, which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia, and renal amyloidosis. Alternative splicing results in two isoforms that vary in the carboxy-terminus.{{cite web | title = Entrez Gene: FGA fibrinogen alpha chain| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2243}}

Fibrinogen alpha chain has been shown to interact with tissue plasminogen activator.{{cite journal | vauthors = Tsurupa G, Medved L | title = Identification and characterization of novel tPA- and plasminogen-binding sites within fibrin(ogen) alpha C-domains | journal = Biochemistry | volume = 40 | issue = 3 | pages = 801–808 | date = Jan 2001 | pmid = 11170397 | doi = 10.1021/bi001789t }}{{cite journal | vauthors = Ichinose A, Takio K, Fujikawa K | title = Localization of the binding site of tissue-type plasminogen activator to fibrin | journal = The Journal of Clinical Investigation | volume = 78 | issue = 1 | pages = 163–169 | date = Jul 1986 | pmid = 3088041 | pmc = 329545 | doi = 10.1172/JCI112546 }}

• Fibrinogen gamma chain

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Doolittle RF | title = Fibrinogen and fibrin | journal = Annual Review of Biochemistry | volume = 53 | pages = 195–229 | year = 1984 | pmid = 6383194 | doi = 10.1146/annurev.bi.53.070184.001211 }}
• {{cite journal | vauthors = Galanakis DK | title = Inherited dysfibrinogenemia: emerging abnormal structure associations with pathologic and nonpathologic dysfunctions | journal = Seminars in Thrombosis and Hemostasis | volume = 19 | issue = 4 | pages = 386–395 | year = 1994 | pmid = 8140431 | doi = 10.1055/s-2007-993290 | s2cid = 739367 }}
• {{cite journal | vauthors = Herrick S, Blanc-Brude O, Gray A, Laurent G | title = Fibrinogen | journal = The International Journal of Biochemistry & Cell Biology | volume = 31 | issue = 7 | pages = 741–746 | date = Jul 1999 | pmid = 10467729 | doi = 10.1016/S1357-2725(99)00032-1 }}
• {{cite journal | vauthors = Bennett JS | title = Platelet-fibrinogen interactions | journal = Annals of the New York Academy of Sciences | volume = 936 | pages = 340–354 | year = 2001 | issue = 1 | pmid = 11460491 | doi = 10.1111/j.1749-6632.2001.tb03521.x | bibcode = 2001NYASA.936..340B | s2cid = 25431334 }}
• {{cite journal | vauthors = Redman CM, Xia H | title = Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion | journal = Annals of the New York Academy of Sciences | volume = 936 | pages = 480–495 | year = 2001 | pmid = 11460506 | doi = 10.1111/j.1749-6632.2001.tb03535.x | s2cid = 31741202 }}
• {{cite journal | vauthors = Matsuda M, Sugo T | title = Structure and function of human fibrinogen inferred from dysfibrinogens | journal = International Journal of Hematology | volume = 76 | pages = 352–60 | date = August 2002 | issue = Suppl 1 | pmid = 12430881 | doi = 10.1007/bf03165284 | s2cid = 11165476 }}
• {{cite journal | vauthors = Everse SJ | title = New insights into fibrin (ogen) structure and function | journal = Vox Sanguinis | volume = 83 | pages = 375–82 | date = August 2002 | issue = Suppl 1 | pmid = 12617173 | doi = 10.1111/j.1423-0410.2002.tb05338.x | s2cid = 21813767 }}
• {{cite journal | vauthors = Scott EM, Ariëns RA, Grant PJ | title = Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease | journal = Arteriosclerosis, Thrombosis, and Vascular Biology | volume = 24 | issue = 9 | pages = 1558–1566 | date = September 2004 | pmid = 15217804 | doi = 10.1161/01.ATV.0000136649.83297.bf | s2cid = 21298700 | doi-access = }}
• {{cite journal | vauthors = Lord ST | title = Fibrinogen and fibrin: scaffold proteins in hemostasis | journal = Current Opinion in Hematology | volume = 14 | issue = 3 | pages = 236–241 | date = May 2007 | pmid = 17414213 | doi = 10.1097/MOH.0b013e3280dce58c | s2cid = 31315177 }}
• {{cite journal | vauthors = Cottrell BA, Strong DD, Watt KW, Doolittle RF | title = Amino acid sequence studies on the alpha chain of human fibrinogen. Exact location of cross-linking acceptor sites | journal = Biochemistry | volume = 18 | issue = 24 | pages = 5405–5410 | date = November 1979 | pmid = 518845 | doi = 10.1021/bi00591a023 }}
• {{cite journal | vauthors = Watt KW, Cottrell BA, Strong DD, Doolittle RF | title = Amino acid sequence studies on the alpha chain of human fibrinogen. Overlapping sequences providing the complete sequence | journal = Biochemistry | volume = 18 | issue = 24 | pages = 5410–5416 | date = November 1979 | pmid = 518846 | doi = 10.1021/bi00591a024 }}
• {{cite journal | vauthors = Fretto LJ, Ferguson EW, Steinman HM, McKee PA | title = Localization of the alpha-chain cross-link acceptor sites of human fibrin | journal = The Journal of Biological Chemistry | volume = 253 | issue = 7 | pages = 2184–95 | date = Apr 1978 | doi = 10.1016/S0021-9258(17)38057-2 | pmid = 632262 | doi-access = free }}
• {{cite journal | vauthors = Blombäck B, Hessel B, Hogg D | title = Disulfide bridges in nh2 -terminal part of human fibrinogen | journal = Thrombosis Research | volume = 8 | issue = 5 | pages = 639–658 | date = May 1976 | pmid = 936108 | doi = 10.1016/0049-3848(76)90245-0 }}
• {{cite journal | vauthors = Koopman J, Haverkate F, Grimbergen J, Egbring R, Lord ST | title = Fibrinogen Marburg: a homozygous case of dysfibrinogenemia, lacking amino acids A alpha 461-610 (Lys 461 AAA→stop TAA) | journal = Blood | volume = 80 | issue = 8 | pages = 1972–9 | date = Oct 1992 | pmid = 1391954 | doi = 10.1182/blood.V80.8.1972.1972| doi-access = free }}
• {{cite journal | vauthors = Fu Y, Weissbach L, Plant PW, Oddoux C, Cao Y, Liang TJ, Roy SN, Redman CM, Grieninger G | title = Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and gamma subunits | journal = Biochemistry | volume = 31 | issue = 48 | pages = 11968–11972 | date = December 1992 | pmid = 1457396 | doi = 10.1021/bi00163a002 }}
• {{cite journal | vauthors = Martin PD, Robertson W, Turk D, Huber R, Bode W, Edwards BF | title = The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution | journal = The Journal of Biological Chemistry | volume = 267 | issue = 11 | pages = 7911–20 | date = Apr 1992 | doi = 10.1016/S0021-9258(18)42599-9 | pmid = 1560020 | doi-access = free }}
• {{cite journal | vauthors = Stubbs MT, Oschkinat H, Mayr I, Huber R, Angliker H, Stone SR, Bode W | title = The interaction of thrombin with fibrinogen. A structural basis for its specificity | journal = European Journal of Biochemistry | volume = 206 | issue = 1 | pages = 187–195 | date = May 1992 | pmid = 1587268 | doi = 10.1111/j.1432-1033.1992.tb16916.x }}
• {{cite journal | vauthors = Maekawa H, Yamazumi K, Muramatsu S, Kaneko M, Hirata H, Takahashi N, Arocha-Piñango CL, Rodriguez S, Nagy H, Perez-Requejo JL | title = Fibrinogen Lima: a homozygous dysfibrinogen with an A alpha-arginine-141 to serine substitution associated with extra N-glycosylation at A alpha-asparagine-139. Impaired fibrin gel formation but normal fibrin-facilitated plasminogen activation catalyzed by tissue-type plasminogen activator | journal = The Journal of Clinical Investigation | volume = 90 | issue = 1 | pages = 67–76 | date = Jul 1992 | pmid = 1634621 | pmc = 443064 | doi = 10.1172/JCI115857 }}
• {{cite journal | vauthors = Maekawa H, Yamazumi K, Muramatsu S, Kaneko M, Hirata H, Takahashi N, de Bosch NB, Carvajal Z, Ojeda A, Arocha-Piñango CL | title = An A alpha Ser-434 to N-glycosylated Asn substitution in a dysfibrinogen, fibrinogen Caracas II, characterized by impaired fibrin gel formation | journal = The Journal of Biological Chemistry | volume = 266 | issue = 18 | pages = 11575–81 | date = Jun 1991 | doi = 10.1016/S0021-9258(18)98995-7 | pmid = 1675636 | doi-access = free }}
• {{cite journal | vauthors = Wu C, Chung AE | title = Potential role of entactin in hemostasis. Specific interaction of entactin with fibrinogen A alpha and B beta chains | journal = The Journal of Biological Chemistry | volume = 266 | issue = 28 | pages = 18802–7 | date = Oct 1991 | doi = 10.1016/S0021-9258(18)55134-6 | pmid = 1680863 | doi-access = free }}

{{refend}}

{{PDB Gallery|geneid=2243}}

{{Coagulation}}