flavodoxin fold

IMage:3chy_flavodoxin_fold.png of CheY (a regulator of the chemotactic response in bacteria, PDB accession code 3CHY), which adopts the flavodoxin fold. Ribbon is colored from blue (N-terminus) to red (C-terminus).]]

The flavodoxin fold is a common α/β protein fold, second only to the TIM barrel fold. It has three layers, with two α-helical layers sandwiching a 5-stranded parallel β-sheet. The order of strands within the sheet is 2-1-3-4-5.

This motif is present for example in lactate dehydrogenase ({{PDB|1A5Z}}) or phosphoglycerate kinase ({{PDB|1FW8}}).{{cite journal | vauthors = Kalinowska B, Banach M, Wiśniowski Z, Konieczny L, Roterman I | title = Is the hydrophobic core a universal structural element in proteins? | journal = Journal of Molecular Modeling | volume = 23 | issue = 7 | pages = 205 | date = July 2017 | pmid = 28623601 | pmc = 5487895 | doi = 10.1007/s00894-017-3367-z }}