gamma-glutamyl hydrolase
{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{Infobox enzyme
| Name = Gamma-glutamyl hydrolase
| EC_number = 3.4.19.9
| CAS_number = 9074-87-7
| GO_code =
| image =
| width =
| caption =
}}
{{Infobox_gene}}
Gamma-glutamyl hydrolase is an enzyme{{cite journal |vauthors=Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J | title = The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells | journal = Biochim. Biophys. Acta | volume = 1164 | issue = 3 | pages = 227–35 |date=August 1993 | pmid = 8343522 | doi = 10.1016/0167-4838(93)90253-n}}{{cite journal |vauthors=Yao R, Rhee MS, Galivan J | title = Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells | journal = Mol. Pharmacol. | volume = 48 | issue = 3 | pages = 505–11 |date=September 1995 | pmid = 7565632 }}{{cite journal |vauthors=Yao R, Schneider E, Ryan TJ, Galivan J | title = Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 19 | pages = 10134–8 |date=September 1996 | pmid = 8816764 | pmc = 38349 | doi = 10.1073/pnas.93.19.10134| doi-access = free | bibcode = 1996PNAS...9310134Y }}{{cite journal |vauthors=Yao R, Nimec Z, Ryan TJ, Galivan J | title = Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase | journal = J. Biol. Chem. | volume = 271 | issue = 15 | pages = 8525–8 |date=April 1996 | pmid = 8621474 | doi = 10.1074/jbc.271.15.8525| doi-access = free }} that catalyses the following chemical reaction:
: Hydrolysis of a gamma-glutamyl bond
This lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH.
In humans, gamma-glutamyl hydrolase is encoded by the GGH gene.{{cite journal |vauthors=Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R | title = Structural organization of the human gamma-glutamyl hydrolase gene | journal = Gene | volume = 238 | issue = 2 | pages = 463–70 |date=Dec 1999 | pmid = 10570974 | doi =10.1016/S0378-1119(99)00362-5 }}{{cite web| title = Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8836| access-date = 2017-08-31| archive-date = 2022-12-12| archive-url = https://web.archive.org/web/20221212130517/https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8836| url-status = live}} This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.
Nomenclature
Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.
Interactive pathway map
{{FluoropyrimidineActivity WP1601|highlight=GGH_(gene)}}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Galivan J, Ryan T, Rhee M, etal |title=Glutamyl hydrolase: properties and pharmacologic impact |journal=Semin. Oncol. |volume=26 |issue= 2 Suppl 6 |pages= 33–7 |year= 1999 |pmid= 10598552 }}
- {{cite journal |vauthors=O'Connor BM, Rotundo RF, Nimec Z, etal |title=Secretion of gamma-glutamyl hydrolase in vitro |journal=Cancer Res. |volume=51 |issue= 15 |pages= 3874–81 |year= 1991 |pmid= 1713122 }}
- {{cite journal |vauthors=Chandler CJ, Wang TT, Halsted CH |title=Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization |journal=J. Biol. Chem. |volume=261 |issue= 2 |pages= 928–33 |year= 1986 |doi=10.1016/S0021-9258(17)36185-9 |pmid= 2867095 |doi-access=free }}
- {{cite journal |vauthors=Wang TT, Chandler CJ, Halsted CH |title=Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization |journal=J. Biol. Chem. |volume=261 |issue= 29 |pages= 13551–5 |year= 1986 |doi=10.1016/S0021-9258(18)67054-1 |pmid= 3759978 |doi-access=free }}
- {{cite journal |vauthors=Yao R, Nimec Z, Ryan TJ, Galivan J |title=Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8525–8 |year= 1996 |pmid= 8621474 |doi=10.1074/jbc.271.15.8525 |doi-access=free }}
- {{cite journal |vauthors=Rhee MS, Lindau-Shepard B, Chave KJ, etal |title=Characterization of human cellular gamma-glutamyl hydrolase |journal=Mol. Pharmacol. |volume=53 |issue= 6 |pages= 1040–6 |year= 1998 |pmid= 9614206 }}
- {{cite journal |vauthors=Li H, Ryan TJ, Chave KJ, Van Roey P |title=Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substrate |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24522–9 |year= 2002 |pmid= 11953431 |doi= 10.1074/jbc.M202020200 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Basrur V, Yang F, Kushimoto T, etal |title=Proteomic analysis of early melanosomes: identification of novel melanosomal proteins |journal=J. Proteome Res. |volume=2 |issue= 1 |pages= 69–79 |year= 2003 |pmid= 12643545 |doi=10.1021/pr025562r }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=He P, Varticovski L, Bowman ED, etal |title=Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray |journal=Hum. Pathol. |volume=35 |issue=10 |pages=1196–209 |year=2004 |pmid=15492986 |doi=10.1016/j.humpath.2004.06.014 |url=https://zenodo.org/record/1259009 |access-date=2020-09-10 |archive-date=2022-10-15 |archive-url=https://web.archive.org/web/20221015072716/https://zenodo.org/record/1259009 |url-status=live }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal |vauthors=Eisele LE, Chave KJ, Lehning AC, Ryan TJ |title=Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer |journal=Biochim. Biophys. Acta |volume=1764 |issue= 9 |pages= 1479–86 |year= 2006 |pmid= 16945597 |doi= 10.1016/j.bbapap.2006.06.008 }}
- {{cite journal |vauthors=Chi A, Valencia JC, Hu ZZ, etal |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135–44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
- {{cite journal |vauthors=Hayashi H, Fujimaki C, Inoue K, etal |title=Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population |journal=Biol. Pharm. Bull. |volume=30 |issue= 4 |pages= 839–41 |year= 2007 |pmid= 17409534 |doi=10.1248/bpb.30.839 |doi-access=free }}
{{refend}}
External links
- {{MeshName|Gamma-glutamyl+hydrolase}}
- {{PDBe-KB2|Q92820|Gamma-glutamyl hydrolase}}
{{PDB Gallery|geneid=8836}}
{{Proteases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}