glucuronate reductase

{{infobox enzyme

| Name = L-glucuronate reductase

| EC_number = 1.1.1.19

| CAS_number = 9028-29-9

| GO_code = 0047939

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In enzymology, a glucuronate reductase ({{EC number|1.1.1.19}}) is an enzyme that catalyzes the chemical reaction

:L-gulonate + NADP⁺ $\backslash rightleftharpoons$ D-glucuronate + NADPH + H⁺

Thus, the two substrates of this enzyme are L-gulonate and NADP⁺, whereas its 3 products are D-glucuronate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is L-gulonate:NADP⁺ 6-oxidoreductase. Other names in common use include aldehyde reductase, L-hexonate:NADP dehydrogenase, TPN-L-gulonate dehydrogenase, aldehyde reductase II, NADP-L-gulonate dehydrogenase, D-glucuronate dehydrogenase, D-glucuronate reductase, and L-glucuronate reductase (incorrect). This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.