growth factor-like domain
{{Pfam_box
| Symbol = APP_CU_bd
| Name = Amyloid precursor N-terminal
| image = 1mwp gfld.png
| width = 200
| caption =The GFLD region of amyloid precursor protein
| Pfam = PF02177
| InterPro = IPR008154
| SMART = SM00006
| PROSITE =
| SCOP = 1mwp
| TCDB =
| PDB= {{PDB2|1mwp}}, {{PDB2|1owt}}, {{PDB2|2fjz}}, {{PDB2|2fk1}}, {{PDB2|2fk2}}, {{PDB2|2fk3}}, {{PDB2|2fkl}}, {{PDB2|2fma}}
}}
A growth factor-like domain (GFLD) is a protein domain structurally related to epidermal growth factor, which has a high binding affinity for the epidermal growth factor receptor. As structural domains within larger proteins, GFLD regions commonly bind calcium ions. A subtype present in the N-terminal region of the amyloid precursor protein is a member of the heparin-binding class of GFLDs and may itself have growth factor function, particularly in promoting neuronal development.
References
{{refbegin}}
- {{cite journal | vauthors = Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW | title = Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein | journal = Nature Structural Biology | volume = 6 | issue = 4 | pages = 327–31 | date = April 1999 | pmid = 10201399 | doi = 10.1038/7562 | s2cid = 30925432 }}
{{refend}}
{{protein-stub}}