growth factor receptor inhibitor
{{Short description|Class of compounds}}
Growth factor receptor inhibitors (growth factor inhibitors, growth factor receptor blockers, growth factor blockers, growth factor receptor antagonists, growth factor antagonists) are drugs that target the growth factor receptors of cells. They interfere with binding of the growth factor to the corresponding growth factor receptors, impeding cell growth and are used medically to treat cancer.[http://www.cancerresearchuk.org/cancer-help/about-cancer/treatment/biological/types/cancer-growth-blockers Cancer growth blockers], Cancer Research UK[http://jco.ascopubs.org/content/21/14/2787.full Status of Epidermal Growth Factor Receptor Antagonists in the Biology and Treatment of Cancer], Journal of Clinical Oncology.
Drugs of this type include those that target the epidermal growth factor receptors of epidermal cells (EGFR inhibitors){{cite journal|last1=Kris|first1=Mark G.|title=Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients With Non–Small Cell Lung Cancer:A Randomized Trial|journal=JAMA|volume=290|issue=16|year=2003|pages=2149–58|issn=0098-7484|doi=10.1001/jama.290.16.2149|pmid=14570950|doi-access=}} and those that target vascular endothelial growth factor receptors (VEGFR inhibitors).{{cite journal|last1=Strumberg|first1=D.|title=Phase I Clinical and Pharmacokinetic Study of the Novel Raf Kinase and Vascular Endothelial Growth Factor Receptor Inhibitor BAY 43-9006 in Patients With Advanced Refractory Solid Tumors|journal=Journal of Clinical Oncology|volume=23|issue=5|year=2004|pages=965–972|issn=0732-183X|doi=10.1200/JCO.2005.06.124|doi-access=free}}
Growth factor receptor inhibitors in cancer treatment and research
In cancer treatment, growth factor receptor inhibitors have been used to target cancer cells.
In cancer research, growth factor receptor inhibitors have been applied to protect normal cells selectively from the toxic side-effects of chemotherapy targeted against cancer cells.{{cite journal|last=Blagosklonny|first=Mikhail|author2=Pardee|title=Exploiting Cancer Cell Cycling for Selective Protection of Normal Cells|journal=Cancer Research|date=June 1, 2001|volume=61|page=4310|url=http://cancerres.aacrjournals.org/content/61/11/4301.full}}
References
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Further reading
- {{cite journal|last1=Fry|first1=D.|last2=Kraker|first2=A.|last3=McMichael|first3=A|last4=Ambroso|first4=L.|last5=Nelson|first5=J.|last6=Leopold|first6=W.|last7=Connors|first7=R.|last8=Bridges|first8=A.|title=A specific inhibitor of the epidermal growth factor receptor tyrosine kinase|journal=Science|volume=265|issue=5175|year=1994|pages=1093–1095|issn=0036-8075|doi=10.1126/science.8066447|pmid=8066447 |bibcode=1994Sci...265.1093F }}
External links
- [https://www.todayhealthplan.com/growth-factor-plus-vs-peak-height-pills-review/ Growth Factor Plus Reviews] at the todayhealthplan.com website
- [https://www.drugs.com/drug-class/egfr-inhibitors.html EGFR inhibitors] at the Drugs.com website.
- [https://www.drugs.com/drug-class/her2-inhibitors.html HER2 inhibitors] at the Drugs.com website.
- [https://www.drugs.com/drug-class/vegf-vegfr-inhibitors.html VEGF/VEGFR inhibitors] at the Drugs.com website.
- [http://www.cancerresearchuk.org/cancer-help/about-cancer/treatment/biological/types/cancer-growth-blockers Cancer growth blockers] at the Cancer Research UK website.
- [http://jco.ascopubs.org/content/21/14/2787.full Status of Epidermal Growth Factor Receptor Antagonists in the Biology and Treatment of Cancer] at the Journal of Clinical Oncology website.
- [http://cancerres.aacrjournals.org/content/61/11/4301.full Exploiting Cancer Cell Cycling for Selective Protection of Normal Cells] at the Cancer Research (Journal) website.
{{Growth factor receptor modulators}}