hemogenic endothelium

Hemogenic endothelium or haemogenic endothelium{{cite journal |last1=Yoshimoto |first1=M |last2=Yoder |first2=MC |title=Developmental biology: Birth of the blood cell. |journal=Nature |date=12 February 2009 |volume=457 |issue=7231 |pages=801–3 |doi=10.1038/457801a |pmid=19212393 |pmc=2766277 |bibcode=2009Natur.457..801Y }} is a special subset of endothelial cells scattered within blood vessels that can differentiate into haematopoietic cells.{{cite journal |last1=Swiers |first1=G |last2=Rode |first2=C |last3=Azzoni |first3=E |last4=de Bruijn |first4=MF |title=A short history of hemogenic endothelium. |journal=Blood Cells, Molecules & Diseases |date=December 2013 |volume=51 |issue=4 |pages=206–12 |doi=10.1016/j.bcmd.2013.09.005 |pmid=24095001 |pmc=4700588 }}

The development of hematopoietic cells in the embryo proceeds sequentially from mesoderm through the hemangioblast to the hemogenic endothelium and hematopoietic progenitors.{{cite journal |last1=Lancrin |first1=C |last2=Sroczynska |first2=P |last3=Stephenson |first3=C |last4=Allen |first4=T |last5=Kouskoff |first5=V |last6=Lacaud |first6=G |title=The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. |journal=Nature |date=12 February 2009 |volume=457 |issue=7231 |pages=892–5 |doi=10.1038/nature07679 |pmid=19182774 |pmc=2661201 |bibcode=2009Natur.457..892L }} The relationship between the hemogenic endothelium and the hemangioblast is not clearly understood.