hepsin

{{Infobox enzyme

| Name = Hepsin

| EC_number = 3.4.21.106

| CAS_number = 112398-23-9

| GO_code =

| image =

| width =

| caption =

}}

Hepsin ({{EC number|3.4.21.106}}) is an enzyme.{{cite journal | vauthors = Zhukov A, Hellman U, Ingelman-Sundberg M | title = Purification and characterization of hepsin from rat liver microsomes | journal = Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology | volume = 1337 | issue = 1 | pages = 85–95 | date = January 1997 | pmid = 9003440 | doi = 10.1016/s0167-4838(96)00152-5 }}{{cite journal | vauthors = Kazama Y, Hamamoto T, Foster DC, Kisiel W | title = Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation | journal = The Journal of Biological Chemistry | volume = 270 | issue = 1 | pages = 66–72 | date = January 1995 | pmid = 7814421 | doi = 10.1074/jbc.270.1.66 | doi-access = free }}{{cite journal | vauthors = Torres-Rosado A, O'Shea KS, Tsuji A, Chou SH, Kurachi K | title = Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 15 | pages = 7181–5 | date = August 1993 | pmid = 8346233 | pmc = 47100 | doi = 10.1073/pnas.90.15.7181 | bibcode = 1993PNAS...90.7181T | doi-access = free }} This enzyme catalyses the following chemical reaction

: Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys

This type-II membrane-associated serine peptidase plays a role in cell growth and development.