heterologous vaccine

{{Short description|Vaccine using different types for priming and boosting}}

A homologous booster shot involves the administration of the same vaccine as previously administered, while a heterologous booster shot involves the administration of a different vaccine.{{cite journal |vauthors=Orlandi C, Stefanetti G, Barocci S, Buffi G, Diotallevi A, Rocchi E, Ceccarelli M, Peluso S, Vandini D, Carlotti E, Magnani M, Galluzzi L, Casabianca A |date=13 May 2023 |title=Comparing Heterologous and Homologous COVID-19 Vaccination: A Longitudinal Study of Antibody Decay |journal=Viruses |volume=15 |issue=5 |page=1162 |doi=10.3390/v15051162 |doi-access=free |pmc=10222288 |pmid=37243247}}

"Heterologous prime-boost immunization is administration of two different vectors or delivery systems expressing the same or overlapping antigenic inserts."{{cite web |title=WHO Technical Consultation: Heterologous Prime-Boost Immunization in Ebola vaccine development and testing, licensure and use; 21 November 2014 |url=https://www.who.int/immunization/research/meetings_workshops/Agenda_ebola_primeboost_nov14.pdf |website=World Health Organization |access-date=10 December 2021 |location=Geneva |date=2015-02-09 |archive-date=10 December 2021 |archive-url=https://web.archive.org/web/20211210211955/https://www.who.int/immunization/research/meetings_workshops/Agenda_ebola_primeboost_nov14.pdf |url-status=live }}

"An effective vaccine usually requires more than one time immunization in the form of prime-boost. Traditionally the same vaccines are given multiple times as homologous boosts. New findings suggested that prime-boost can be done with different types of vaccines containing the same antigens. In many cases such heterologous prime-boost can be more immunogenic than homologous prime-boost."{{cite journal |last1=Lu |first1=S |title=Heterologous prime-boost vaccination. |journal=Current Opinion in Immunology |date=June 2009 |volume=21 |issue=3 |pages=346–51 |doi=10.1016/j.coi.2009.05.016 |pmid=19500964|pmc=3743086 }}