homoglutathione synthase

{{Short description|Class of enzymes}}

{{infobox enzyme

| Name = Homoglutathione synthase

| EC_number = 6.3.2.23

| CAS_number = 113875-72-2

| GO_code = 0047983

| image =

| width =

| caption =

}}

In enzymology, a homoglutathione synthase ({{EnzExplorer|6.3.2.23}}) is an enzyme that catalyzes the chemical reaction

:ATP + γ-L-glutamyl-L-cysteine + β-alanine $\backslash rightleftharpoons$ ADP + phosphate + γ-Lglutamyl-L-cysteinyl-β-alanine

The 3 substrates of this enzyme are ATP, gamma-L-glutamyl-L-cysteine, and beta-alanine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamyl-L-cysteinyl-beta-alanine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming). Other names in common use include homoglutathione synthetase, and beta-alanine specific hGSH synthetase.