hydrocholeretic

Hydrocholeretics are substances that increase the volume of secretion of bile from the liver without increasing the amount of solids secreted.[https://books.google.com/books?id=LKy0weDEFp8C&dq=choleretic+hydrocholeretic&pg=PA610 Textbook of Biochemistry and Human Biology, by G. P. Talwar, Talwar & Srivastava (eds.), L. M. Srivastava, p.610.] Some substances can result in decreased solid production, possibly due to circulatory effects.{{Cite journal | doi=10.1126/science.115.2980.142| title=The Effect of Choleretic and of Hydrocholeretic Agents on Bile Flow and Bile Solids in the Isolated Perfused Liver| journal=Science| volume=115| issue=2980| pages=142–143| year=1952| last1=Brauer| first1=R. W.| last2=Pessotti| first2=R. L.| pmid=14913193| bibcode=1952Sci...115..142B}}

Cyclobutyrol is a compound commonly used as a hydrocholeretic. Its effects in rats include a dose-dependent increase in bile flow, sodium, potassium, chloride and bicarbonate outputs and reduced bile acid concentrations.{{cite journal |last1=Monte |first1=MJ |title=Choleretic mechanism and effects of cyclobutyrol in the rat: dose-response relationship. |journal= Biomedica Biochimica Acta|date=1990 |volume=49 |issue=1 |pages=83–90 |pmid=2360911 }}