hydrophilization

{{Primary sources|date=August 2022}}

Hydrophilization is a process used on hydrophobic drugs to increase their release rate from capsules, which depends on the rate of dissolution, by covering the surfaces of their particles with minute droplets of a dissolved hydrophilic polymer (such as methyl cellulose or hydroxyethyl cellulose).{{Cite journal |last1=Panraksa |first1=Pattaraporn |last2=Udomsom |first2=Suruk |last3=Rachtanapun |first3=Pornchai |last4=Chittasupho |first4=Chuda |last5=Ruksiriwanich |first5=Warintorn |last6=Jantrawut |first6=Pensak |date=November 2020 |title=Hydroxypropyl Methylcellulose E15: A Hydrophilic Polymer for Fabrication of Orodispersible Film Using Syringe Extrusion 3D Printer |journal=Polymers |language=en |volume=12 |issue=11 |pages=2666 |doi=10.3390/polym12112666 |doi-access=free |pmid=33198094 |pmc=7696250 |issn=2073-4360}}{{cite journal |vauthors=Lerk CF, Lagas M, Fell JT, Nauta P |title=Effect of hydrophilization of hydrophobic drugs on release rate from capsules |journal=Journal of Pharmaceutical Sciences |volume=67 |issue=7 |pages=935–9 |date=July 1978 |pmid=660511 |doi=10.1002/jps.2600670716}} In tablet or capsule formulations, this enhances the dissolution and disintegration of the drug.