hypertrophy

{{short description|Increase in the volume of an organ or tissue due to the enlargement of its component cells}}

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{{Infobox medical condition (new)

| name = Hypertrophy

| image = Hyperplasia vs Hypertrophy.svg

| caption = Hypertrophy results from an increase in cell size, whereas hyperplasia stems from an increase in cell number.|

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Hypertrophy is the increase in the volume of an organ or tissue due to the enlargement of its component cells.{{cite web|last1=Hernandez|first1=Richard|last2=Kravitz|first2=Len|title=Skeletal muscle hypertrophy|url=https://www.unm.edu/~lkravitz/Article%20folder/hypertrophy.html|website=www.unm.edu}} It is distinguished from hyperplasia, in which the cells remain approximately the same size but increase in number.{{Cite web|title=Hyperplasia: MedlinePlus Medical Encyclopedia|url=https://medlineplus.gov/ency/article/003441.htm|access-date=2023-02-19|website=medlineplus.gov|language=en}} Although hypertrophy and hyperplasia are two distinct processes, they frequently occur together, such as in the case of the hormonally induced proliferation and enlargement of the cells of the uterus during pregnancy.

Eccentric hypertrophy is a type of hypertrophy where the walls and chamber of a hollow organ undergo growth in which the overall size and volume are enlarged. It is applied especially to the left ventricle of heart.{{citation | last=Kusumoto | first=F. M. | year=2004 | title=Cardiovascular Pathophysiology | publisher=Hayes Barton Press | isbn=978-1-59377-189-8 | url=https://books.google.com/books?id=FHT_w_gUeK4C&q=Eccentric+hypertrophy&pg=PA22 | pages=20–22 }}{{Dead link|date=August 2024 |bot=InternetArchiveBot |fix-attempted=yes }} Sarcomeres are added in series, as for example in dilated cardiomyopathy (in contrast to hypertrophic cardiomyopathy, a type of concentric hypertrophy, where sarcomeres are added in parallel).