indolepyruvate decarboxylase

{{infobox enzyme

| Name = indolepyruvate decarboxylase

| EC_number = 4.1.1.74

| CAS_number = 9074-92-4

| GO_code = 0047434

| image =

| width =

| caption =

}}

The enzyme indolepyruvate decarboxylase ({{EnzExplorer|4.1.1.74}}) catalyzes the chemical reaction

:3-(indol-3-yl)pyruvate $\rightleftharpoons$ 2-(indol-3-yl)acetaldehyde + CO₂

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]. Other names in common use include indol-3-yl-pyruvate carboxy-lyase, and 3-(indol-3-yl)pyruvate carboxy-lyase. This enzyme participates in tryptophan metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code {{PDB link|1OVM}}.

References

{{cite journal | vauthors = Koga J | title = Structure and function of indolepyruvate decarboxylase, a key enzyme in indole-3-acetic acid biosynthesis | journal = Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology | volume = 1249 | issue = 1 | pages = 1–13 | date = May 1995 | pmid = 7766676 | doi = 10.1016/0167-4838(95)00011-I }}

Category:EC 4.1.1

Category:Enzymes of known structure