interleukin 11 receptor alpha subunit

{{Short description|Protein-coding gene in the species Homo sapiens}}

Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.{{cite web | title = Entrez Gene: IL11RA interleukin 11 receptor, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3590}}

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.{{cite web | title = Entrez Gene: IL11RA interleukin 11 receptor, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3590}}

References

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{{cite journal |vauthors=Chérel M, Sorel M, Apiou F, etal |title=The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping |journal=Genomics |volume=32 |issue= 1 |pages= 49–53 |year= 1996 |pmid= 8786120 |doi=10.1006/geno.1996.0075 }}
{{cite journal |vauthors=Van Leuven F, Stas L, Hilliker C, etal |title=Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13 |journal=Genomics |volume=31 |issue= 1 |pages= 65–70 |year= 1996 |pmid= 8808281 |doi= 10.1006/geno.1996.0010 }}
{{cite journal |vauthors=Magrangeas F, Pitiot G, Dubois S, etal |title=Cotranscription and intergenic splicing of human galactose-1-phosphate uridylyltransferase and interleukin-11 receptor alpha-chain genes generate a fusion mRNA in normal cells. Implication for the production of multidomain proteins during evolution |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 16005–10 |year= 1998 |pmid= 9632650 |doi=10.1074/jbc.273.26.16005 |doi-access=free }}
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{{cite journal |vauthors=Tsimanis A, Shtalrid M, Shvidel L, etal |title=Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma |journal=Leuk. Lymphoma |volume=45 |issue= 11 |pages= 2315–9 |year= 2005 |pmid= 15512823 |doi= 10.1080/10428190412331283161 |s2cid=27011485 }}
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{{cite journal |vauthors=Karube K, Ohshima K, Suzumiya J, etal |title=Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha |journal=Ann. Oncol. |volume=17 |issue= 1 |pages= 110–6 |year= 2006 |pmid= 16291580 |doi= 10.1093/annonc/mdj064 |doi-access= free }}
{{cite journal |vauthors=Hanavadi S, Martin TA, Watkins G, etal |title=Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer |journal=Ann. Surg. Oncol. |volume=13 |issue= 6 |pages= 802–8 |year= 2006 |pmid= 16614887 |doi= 10.1245/ASO.2006.05.028 |s2cid=5693500 }}
{{cite journal |vauthors=Yoshizaki A, Nakayama T, Yamazumi K, etal |title=Expression of interleukin (IL)-11 and IL-11 receptor in human colorectal adenocarcinoma: IL-11 up-regulation of the invasive and proliferative activity of human colorectal carcinoma cells |journal=Int. J. Oncol. |volume=29 |issue= 4 |pages= 869–76 |year= 2006 |pmid= 16964382 |doi= 10.3892/ijo.29.4.869|doi-access=free }}
{{cite journal |vauthors=Nakayama T, Yoshizaki A, Izumida S, etal |title=Expression of interleukin-11 (IL-11) and IL-11 receptor alpha in human gastric carcinoma and IL-11 upregulates the invasive activity of human gastric carcinoma cells |journal=Int. J. Oncol. |volume=30 |issue= 4 |pages= 825–33 |year= 2007 |pmid= 17332920 |doi= 10.3892/ijo.30.4.825|doi-access=free }}

interleukin 11 receptor alpha subunit

References

Further reading