iomeprol
{{Short description|Chemical compound}}
{{Use dmy dates|date=November 2024}}
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{{Infobox drug
| image = Iomeprol-Structural Formula V.1.svg
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| pronounce =
| tradename = Iomervu, others
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| MedlinePlus =
| DailyMedID = Iomeprol
| pregnancy_AU =
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| routes_of_administration = Intravenous, intra-arterial
| class =
| ATC_prefix = V08
| ATC_suffix = AB10
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| legal_US = Rx-only
| legal_US_comment = [https://web.archive.org/web/20241204060629/https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/216017s000,216017s000lbl.pdf fda.gov]
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| legal_status = Rx-only
| bioavailability =
| protein_bound =
| metabolism = none
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| onset =
| elimination_half-life = 109±20 min
| duration_of_action =
| excretion = Kidney
| CAS_number = 78649-41-9
| PubChem = 3731
| IUPHAR_ligand =
| DrugBank = DB11705
| ChemSpiderID = 3600
| UNII = 17E17JBP8L
| KEGG = D01719
| ChEBI = 31710
| ChEMBL =
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| synonyms =
| IUPAC_name = 1-N,3-N-bis(2,3-dihydroxypropyl)-5-(2-hydroxy-N-methylacetamido)-2,4,6-triiodobenzene-1,3-dicarboxamide
| C=17 | H=22 | I=3 | N=3 | O=8
| SMILES = Ic1c(c(I)c(c(I)c1N(C(=O)CO)C)C(=O)NCC(O)CO)C(=O)NCC(O)CO
| StdInChI = 1S/C17H22I3N3O8/c1-23(9(29)6-26)15-13(19)10(16(30)21-2-7(27)4-24)12(18)11(14(15)20)17(31)22-3-8(28)5-25/h7-8,24-28H,2-6H2,1H3,(H,21,30)(H,22,31)
| StdInChI_comment =
| StdInChIKey = NJKDOADNQSYQEV-UHFFFAOYSA-N
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Iomeprol, sold under the brand name Imeron among others, is a medication used as a radiocontrast agent in X-ray imaging.{{cite book | vauthors = Rossiter D |title=South African medicines formulary |date=2014 |publisher=Health and Medical Pub. Group .of the South African Medical Association |location=Rondebosch, South Africa |isbn=978-1-875098-30-9 |edition=11th |oclc=869772940}}{{cite book|title=Austria-Codex| veditors = Haberfeld H |at=Iomeron 300 mg J/ml-Infusionsflasche|publisher=Österreichischer Apothekerverlag|location=Vienna|year=2020|language=German}}
Iomeprol was approved for medical use in the United States in November 2024.{{cite web | title=Novel Drug Approvals for 2024 | website=U.S. Food and Drug Administration (FDA) | date=1 October 2024 | url=https://www.fda.gov/drugs/novel-drug-approvals-fda/novel-drug-approvals-2024 | access-date=29 November 2024}}{{cite report | title=New Drug Therapy Approvals 2024 | website=U.S. Food and Drug Administration (FDA) | date=January 2025 | url=https://www.fda.gov/media/184967/download | format=PDF | access-date=21 January 2025 | archive-url=https://web.archive.org/web/20250121045744/https://www.fda.gov/media/184967/download | archive-date=21 January 2025 | url-status=live }}
Side effects
It is classified as a water-soluble, nephrotrophic, low osmolar X-ray contrast medium. Low osmolar non-ionic agents are better tolerated and less likely to cause side effects than the high osmolar ionic agents.
Society and culture
Iomeprol is not metabolized in the human body but excreted in unchanged form.{{medcn|date=January 2025}} It is decomposed slowly and can therefore accumulate in the environment.{{cite journal| vauthors = Pfundstein P, Martin C, Schulz W, Seitz W, Ruth KM, Wille A, Steinbach A, Flottmann D |title=IC-ICP/MS-Analytik|journal=GIT Labor-Fachzeitschrift|date=January 2015|pages=29–31|language=de}}
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References
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