isoflupredone

{{Short description|Chemical compound}}

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| IUPAC_name = (8S,9R,10S,11S,13S,14S,17R)-9-Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

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| CAS_number = 338-95-4

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| class = Corticosteroid; Glucocorticoid

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| PubChem = 127516

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| ChemSpiderID = 113134

| UNII = HYS0B45Z2S

| KEGG = C14484

| ChEBI = 34511

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| C=21 | H=27 | F=1 | O=5

| SMILES = C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@@]43C)F)O

| StdInChI_Ref =

| StdInChI = 1S/C21H27FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h5,7,9,14-16,23,25,27H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1

| StdInChIKey_Ref =

| StdInChIKey = WAIJIHDWAKJCBX-BULBTXNYSA-N

| synonyms = 9α-Fluoroprednisolone; Fluoroprednisolone; Deltafludrocortisone; δ-Fludrocortisone; δ-Fluorocortisone; 1-Dehydro-9α-fluorohydrocortisone; 9α-Fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione

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Isoflupredone, also known as deltafludrocortisone and 9α-fluoroprednisolone, is a synthetic glucocorticoid corticosteroid which was never marketed.{{cite book| vauthors = Elks J |title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA707|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=707–}}{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA573|year=2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=573–}}

Its acetate ester, isoflupredone acetate, is used in veterinary medicine.{{cite web | url = https://www.drugs.com/vet/predef-2x-sterile-aqueous-suspension.html | publisher = drugs.com | title = Predef 2X Sterile Aqueous Suspension}}

References

{{Reflist|2}}

Further reading

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  • {{cite journal | vauthors = Montoliu J, Botey A, Trilla A, Revert L | title = Pseudoprimary aldosteronism from the topical application of 9-alpha-fluorprednisolone to the skin | journal = Clinical Nephrology | volume = 22 | issue = 5 | pages = 262–6 | date = November 1984 | pmid = 6394185 }}

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{{Glucocorticoid receptor modulators}}

Category:Diketones

Category:Organofluorides

Category:Glucocorticoids

Category:Pregnanes

Category:Triols

Category:Abandoned drugs

Category:Hydroxyketones

Category:Primary alcohols

Category:Secondary alcohols

Category:Tertiary alcohols

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