isotuberculosinol synthase

{{Infobox enzyme

| Name = Isotuberculosinol synthase

| EC_number = 3.1.7.9

| CAS_number =

| GO_code =

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Isotuberculosinol synthase ({{EC number|3.1.7.9}}, Rv3378c) is an enzyme with systematic name tuberculosinyl diphosphate diphosphohydrolase (isotuberculosinol forming).{{cite journal | vauthors = Nakano C, Ootsuka T, Takayama K, Mitsui T, Sato T, Hoshino T | title = Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome | journal = Bioscience, Biotechnology, and Biochemistry | volume = 75 | issue = 1 | pages = 75–81 | date = 2011 | pmid = 21228491 | doi = 10.1271/bbb.100570 | doi-access = free }}{{cite journal | vauthors = Hoshino T, Nakano C, Ootsuka T, Shinohara Y, Hara T | title = Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis | journal = Organic & Biomolecular Chemistry | volume = 9 | issue = 7 | pages = 2156–65 | date = April 2011 | pmid = 21290071 | doi = 10.1039/c0ob00884b }} This enzyme catalyses the following chemical reaction

: tuberculosinyl diphosphate + H₂O $\backslash rightleftharpoons$ (13S)-isotuberculosinol + diphosphate

This enzyme is present in species of Mycobacterium that cause tuberculosis.