kynapcin

{{Short description|Class of chemical compounds}}

image:Kynapcin-24.svg of kynapcin-24]]

Kynapcin is a general name for a number of dibenzofuranyl derivatives of the molecule polyozellin, present in the fungus Polyozellus multiplex. Like polyozellin, some kynapcins inhibit prolyl endopeptidase, an enzyme that has a role in processing proteins including amyloid precursor protein. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.{{cite journal |vauthors=Hwang JS, Song KS, Kim WG, Lee TH, Koshino H, Yoo ID |title=Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex |journal=The Journal of Antibiotics |volume=50 |issue=9 |pages=773–777|year=1997|pmid=9360624 |doi=10.7164/antibiotics.50.773|doi-access=free }} Several kynapcins have been found in P. multiplex, each with different chemical properties, including kynapcin-12,{{cite journal |vauthors=Lee HJ, Rhee IK, Lee KB, Yoo ID, Song KS |title=Kynapcin-12, a new p-terphenyl derivative from Polyozellus multiplex, inhibits prolyl endopeptidase |journal=The Journal of Antibiotics |volume=53 |issue=7 |pages=714–719 |year=2000 |pmid=10994814 |doi=10.7164/antibiotics.53.714|doi-access=free }} kynapcin-13 and -28,{{cite journal |vauthors=Kim SI, Park IH, Song KS |title=kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus multiplex |journal=The Journal of Antibiotics |volume=55 |issue=7 |pages=623–628 |year=2002 |pmid=12243451 |doi=10.7164/antibiotics.55.623|doi-access=free }} and -24.{{cite journal |vauthors=Song KS, Raskin I |year=2002 |title=A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex |journal=Journal of Natural Products |volume=65 |issue=1 |pages=76–78 |doi=10.1021/np010194b |pmid=11809072}} A total synthesis of kynapcin-24 was achieved in 2009.{{cite journal |vauthors=Yang LY, Chang CF, Huang YC, Lee YJ, Hu CC, Tseng TH |year=2009 |title=The first total synthesis of kynapcin-24 by palladium catalysis |journal=Synthesis |volume=2009 |issue= 7|pages=1175–1179 |doi=10.1055/s-0028-1087998 }}