large-cell lymphoma
{{More citations needed|date=October 2021}}
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| image = Primary mediastinal large B-cell lymphoma - high mag.jpg
| caption = Micrograph of a primary mediastinal large B-cell lymphoma, a type of large-cell lymphoma. H&E stain.
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| field = Oncology
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The large-cell lymphomas have large cells. One classification system for lymphomas divides the diseases according to the size of the white blood cells that have turned cancerous. A large cell, in this context, has a diameter of 17 to 20 μm.{{cite book |author=Turgeon, Mary Louise |title=Clinical hematology: theory and procedures |url=https://archive.org/details/clinicalhematolo0004turg |url-access=registration |publisher=Lippincott Williams & Wilkins |location=Hagerstown, MD |year=2005 |pages=[https://archive.org/details/clinicalhematolo0004turg/page/221 221] |isbn=0-7817-5007-5}} Other groups of lymphomas in this system are the small-cell lymphomas and mixed-cell lymphomas.
Types
=B cell=
Diffuse large B-cell lymphoma is the most common of the large-cell lymphomas. MeSH now classifies the phrase "large-cell lymphoma" under "Diffuse large B cell lymphoma".{{MeshName|Large+cell+lymphoma}}
Many other B-cell lymphomas feature large cells:{{cn|date=November 2021}}
- Angiocentric lymphoma
- Burkitt's lymphoma
- Follicular large-cell lymphoma
- Immunoblastic lymphoma
- Intravascular large-cell lymphoma
- Primary mediastinal B-cell lymphoma
- T-cell–rich B-cell lymphoma
- Primary splenic lymphoma (rare)
- Primary central nervous system lymphomas, which are often diffuse large-B-cell lymphomas
- Richter's transformation: Diffuse Large B-cell Variant
- 1) ABC subtype (common)
- 2) GCB subtype (rare)
Activated B-Cell Diffuse Large B-Cell Lymphoma, or ABC-DLBCL, is believed to be caused by aberrant activation of a critical intracellular pathway.
This intracellular signaling pathway involved in B-cell activation and proliferation stays constantly activated, driving lymphocytes to proliferate continuously.
The inhibition of this pathway can be induced by a drug known as NEMO Binding Domain, or NBD, a peptide causing increased cell death of malignant lymphocytes.{{citation needed|date=November 2018}}
=T cell=
Less commonly, a large-cell lymphoma may feature T cells. Anaplastic large-cell lymphoma is an example of a large-cell lymphoma that involves T cells. Of the large-cell T-cell lymphomas, it has the best prognosis.{{Citation needed|date=May 2010}}
References
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External links
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{{Lymphoid malignancy}}