large cell neuroendocrine carcinoma of the lung

{{Short description|Human disease}}

Large-cell neuroendocrine carcinoma of the lung (LCNEC of the lung), or pulmonary large-cell neuroendocrine carcinoma (PLCNC), is a highly malignant neoplasm arising from transformed epithelial cells originating in tissues within the pulmonary tree. It is currently considered to be a subtype of large-cell lung carcinoma.

LCNEC is often generically grouped among the non-small-cell lung carcinomas.{{cite book |title=Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart |editor1-last=Travis |editor1-first=William D |editor2-last=Brambilla |editor2-first=Elisabeth |editor3-last=Muller-Hermelink |editor3-first=H Konrad |display-editors=3 |editor4-last=Harris |editor4-first=Curtis C |publisher=IARC Press |location=Lyon |year=2004 |series=World Health Organization Classification of Tumours |isbn=978-92-832-2418-1 |url=http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-cover.pdf |accessdate=27 March 2010 |archive-url=https://web.archive.org/web/20090823210304/http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-cover.pdf |archive-date=23 August 2009 |url-status=dead }}

LCNECs often have inactivations of p53 and RB (~40%), or inactivation of TP53 and STK11 or KEAP1 (~40%).{{cite journal |author1=George |author2=Walter |author3=Peifer |author4=Alexandrov |author5=Seidel |author6=Leenders |author7=Maas |author8=Müller |author9=Dahmen |author10=Delhomme |author11=Ardin|author12=Leblay|author13=Byrnes |display-authors=4|title=Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors |journal=Nature Communications |date=2018 |volume=9 |issue=Article number: 1048 |page=1048 |doi=10.1038/s41467-018-03099-x |pmid=29535388 |pmc=5849599 |bibcode=2018NatCo...9.1048G }}