latent TGF-beta binding protein

The latent TGF-beta binding proteins (LTBP) are a family of carrier proteins.

LTBP is a family of secreted multidomain proteins that were originally identified by their association with the latent form of transforming growth factors. They interact with a variety of extracellular matrix proteins and may play a role in the regulation of TGF beta bioavailability.

Genes

{{Infobox protein

| Name = latent transforming growth factor beta binding protein 1

| caption =

| image =

| width =

| HGNCid = 6714

| Symbol = LTBP1

| AltSymbols = TGF-beta1-BP-1

| EntrezGene = 4052

| OMIM = 150390

| RefSeq = NM_206943

| UniProt = Q14766

| PDB =

| ECnumber =

| Chromosome = 2

| Arm = p

| Band = 22

| LocusSupplementaryData = -p21

}}

{{Infobox protein

| Name = latent transforming growth factor beta binding protein 2

| caption =

| image =

| width =

| HGNCid = 6715

| Symbol = LTBP2

| AltSymbols = LTBP3, C14orf141

| EntrezGene = 4053

| OMIM = 602091

| RefSeq = NM_000428

| UniProt = Q14767

| PDB =

| ECnumber =

| Chromosome = 14

| Arm = q

| Band = 24.3

| LocusSupplementaryData =

}}

{{Infobox protein

| Name = latent transforming growth factor beta binding protein 3

| caption =

| image =

| width =

| HGNCid = 6716

| Symbol = LTBP3

| AltSymbols = LTBP2

| EntrezGene = 4054

| OMIM = 602090

| RefSeq = NM_021070

| UniProt = Q9NS15

| PDB =

| ECnumber =

| Chromosome = 11

| Arm = q

| Band = 12

| LocusSupplementaryData =

}}

{{Infobox protein

| Name = latent transforming growth factor beta binding protein 4

| caption =

| image =

| width =

| HGNCid = 6717

| Symbol = LTBP4

| AltSymbols = LTBP-4, LTBP-4L

| EntrezGene = 8425

| OMIM = 604710

| RefSeq = NM_003573

| UniProt = Q8N2S1

| PDB =

| ECnumber =

| Chromosome = 19

| Arm = q

| Band = 13.1

| LocusSupplementaryData = -13.2

}}

References

{{Reflist|refs=

{{cite journal | author = Rifkin DB | title = Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability | journal = J. Biol. Chem. | volume = 280 | issue = 9 | pages = 7409–12 |date=March 2005 | pmid = 15611103 | doi = 10.1074/jbc.R400029200 | doi-access = free}}

{{cite journal |vauthors=Todorovic V, Jurukovski V, Chen Y, Fontana L, Dabovic B, Rifkin DB | title = Latent TGF-beta binding proteins | journal = Int. J. Biochem. Cell Biol. | volume = 37 | issue = 1 | pages = 38–41 |date=January 2005 | pmid = 15381147 | doi = 10.1016/j.biocel.2004.03.011 }}

}}

External links

{{MeshName|Latent+TGF-beta+Binding+Proteins}}
[https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q14766 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Latent-transforming growth factor beta-binding protein 1