leconotide

{{short description|Conotoxin peptide under investigation as an analgesic drug}}

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| CAS_number = 247207-64-3

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| PubChem = 16132255

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| ChemSpiderID = 17288914

| UNII = 2P1P5JB93S

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| C=107 | H=179 | N=35 | O=36 | S=7

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| routes_of_administration = IV

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Leconotide (INN; development codes CNSB004 and AM336; also known as ω-conotoxin CVID) is an ω-conotoxin peptide isolated from the venom of Conus catus which is under investigation as an analgesic drug for the treatment of pain conditions.{{cite book| vauthors = Allerton C, Fox D |title=Pain Therapeutics: Current and Future Treatment Paradigms|url=https://books.google.com/books?id=zUINAgAAQBAJ&pg=PA225|year=2013|publisher=Royal Society of Chemistry|isbn=978-1-84973-645-9|pages=225–}}{{cite book| vauthors = Stephens G, Mochida S|title=Modulation of Presynaptic Calcium Channels|url=https://books.google.com/books?id=2bVEAAAAQBAJ&pg=PA326|date=23 April 2013|publisher=Springer Science & Business Media|isbn=978-94-007-6334-0|pages=326–}}

It acts as an N-type voltage-gated calcium channel (Ca_v2.2) blocker and is highly selective for this channel over the related P/Q-type voltage-gated calcium channel (Ca_v2.1).

Relative to ziconotide, leconotide is advantageous in that it is significantly less toxic, and for that reason can be administered intravenously as opposed to via intrathecal injection.{{cite book|title=Nervous System Diseases: Advances in Research and Treatment: 2011 Edition|url=https://books.google.com/books?id=RQTtLhbqJE4C&pg=PA217|date=9 January 2012|publisher=ScholarlyEditions|isbn=978-1-4649-2221-3|pages=217–}}{{cite journal | vauthors = Kolosov A, Goodchild CS, Cooke I | title = CNSB004 (Leconotide) causes antihyperalgesia without side effects when given intravenously: a comparison with ziconotide in a rat model of diabetic neuropathic pain | journal = Pain Medicine | volume = 11 | issue = 2 | pages = 262–73 | date = February 2010 | pmid = 20002322 | doi = 10.1111/j.1526-4637.2009.00741.x | doi-access = free }}{{cite journal | vauthors = Kolosov A, Aurini L, Williams ED, Cooke I, Goodchild CS | title = Intravenous injection of leconotide, an omega conotoxin: synergistic antihyperalgesic effects with morphine in a rat model of bone cancer pain | journal = Pain Medicine | volume = 12 | issue = 6 | pages = 923–41 | date = June 2011 | pmid = 21539704 | doi = 10.1111/j.1526-4637.2011.01118.x | doi-access = free }}