leporipoxvirus
{{Short description|Genus of viruses}}
{{Use dmy dates|date=April 2017}}
{{Virusbox
| image =
| image_alt =
| image_caption =
| taxon = Leporipoxvirus
| synonyms =
| synonyms_ref =
| subdivision_ranks =
| subdivision =
}}
Leporipoxvirus is a genus of viruses, in the family Poxviridae, in the subfamily Chordopoxvirinae. Lagomorphs and squirrels serve as natural hosts. There are three species in this genus. Diseases associated with this genus include: myxomatosis.{{cite web|title=Viral Zone|url=http://viralzone.expasy.org/all_by_species/153.html|publisher=ExPASy|accessdate=15 June 2015}}{{cite web|title=Virus Taxonomy: 2024 Release|url=https://ictv.global/taxonomy|publisher=International Committee on Taxonomy of Viruses|access-date=23 March 2025}}
Taxonomy
The genus contains the following species, listed by scientific name and followed by the exemplar virus of the species:
- Leporipoxvirus myxoma, Myxoma virus
- Leporipoxvirus shope, Shope fibroma virus, also called Rabbit fibroma virus
- Leporipoxvirus squirrelfibroma, Squirrel fibroma virus
Structure
Life cycle
Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell. Fusion with the plasma membrane to release the core into the host cytoplasm. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins. Assembly of progeny virions starts in cytoplasmic viral factories, producing a spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV). IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV)host receptors, which mediates endocytosis. Replication follows the DNA strand displacement model. DNA-templated transcription is the method of transcription. The virus exits the host cell by existing in occlusion bodies after cell death and remaining infectious until finding another host.
Lagomorph and squirrels serve as the natural host. Transmission routes are fomite, mechanical, and contact.
| class="wikitable sortable" style="text-align:center" | |||||||
| Genus | Host details | Tissue tropism | Entry details | Release details | Replication site | Assembly site | Transmission |
|---|---|---|---|---|---|---|---|
| Leporipoxvirus | Lagomorph; squirrels | None | Glycosaminoglycans | Lysis; budding | Cytoplasm | Cytoplasm | Arthropods; contact |
References
{{Reflist}}
External links
- [http://viralzone.expasy.org/all_by_species/153.html Viralzone: Leporipoxvirus]
- [http://ictvonline.org/virusTaxonomy.asp ICTV]
{{Baltimore classification}}
{{Taxonbar|from=Q16948083}}