levopimaradiene synthase

{{Infobox enzyme

| Name = Levopimaradiene synthase

| EC_number = 4.2.3.32

| CAS_number =

| GO_code =

| image =

| width =

| caption =

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Levopimaradiene synthase (EC 4.2.3.32, PtTPS-LAS, LPS, copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming]) is an enzyme with systematic name (+)-copalyl-diphosphate diphosphate-lyase (abieta-8(14),12-diene-forming).{{cite journal | vauthors = Schepmann HG, Pang J, Matsuda SP | title = Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis | journal = Archives of Biochemistry and Biophysics | volume = 392 | issue = 2 | pages = 263–9 | date = August 2001 | pmid = 11488601 | doi = 10.1006/abbi.2001.2438 }}{{cite journal | vauthors = Ro DK, Bohlmann J | title = Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1) | journal = Phytochemistry | volume = 67 | issue = 15 | pages = 1572–8 | date = August 2006 | pmid = 16497345 | doi = 10.1016/j.phytochem.2006.01.011 }} This enzyme catalyses the following chemical reaction

: (+)-copalyl diphosphate $\backslash rightleftharpoons$ abieta-8(14),12-diene + diphosphate

In Ginkgo, the enzyme catalyses the initial cyclization step in the biosynthesis of ginkgolides.