liranaftate

{{Short description|Chemical compound}}

{{Infobox drug

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| image = Liranaftate.svg

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| tradename = Zefnart

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| routes_of_administration = Topical

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| ATC_prefix = D01

| ATC_suffix = AE25

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| legal_status = JP: Rx-only

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| CAS_number = 88678-31-3

| PubChem = 3936

| ChemSpiderID = 3799

| DrugBank =

| UNII = 5253IGO5X3

| KEGG = D01550

| synonyms = M-732; piritetrate

| IUPAC_name = O-(5,6,7,8-Tetrahydronaphthalen-2-yl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate

| C=18| H=20 | N=2 | O=2 | S=1

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Liranaftate (trade name Zefnart) is a topical antifungal drug.{{cite journal | vauthors = Koga H, Nanjoh Y, Makimura K, Tsuboi R | title = In vitro antifungal activities of luliconazole, a new topical imidazole | journal = Medical Mycology | volume = 47 | issue = 6 | pages = 640–7 | date = 2009 | pmid = 19115136 | doi = 10.1080/13693780802541518 | doi-access = free }} It is used as a 2% cream used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch).{{cite press release | url = https://www.torii.co.jp/en/release/2007/20070706.html | title = Torii Pharmaceutical to Launch Antifungal Agent for External Use, "ZEFNART SOLUTION 2%", in Japan | publisher = Torii Pharmaceutical Co. | access-date = June 27, 2021 }} It was approved for use in Japan in August 2000.{{cite web | url = https://drugs.ncats.io/drug/5253IGO5X3 | title = Liranaftate | website = ncats.io | access-date = June 27, 2021 }}{{cite web | url = https://adisinsight.springer.com/drugs/800003128 | title = Liranaftate | publisher = Adis Insight | access-date = June 27, 2021 }}

Liranaftate works by inhibiting the fungal enzyme squalene epoxidase that is necessary for the fungus to synthesize sterols which are essential for cell membrane integrity.{{pubchem|3936}}