locus suicide recombination

Locus suicide recombination (LSR) constitutes a variant form of class switch recombination that eliminates all immunoglobulin heavy chain constant genes.{{cite book | last=Acton | first=Q.A. | title=Immunoglobulins—Advances in Research and Application: 2013 Edition | publisher=ScholarlyEditions | year=2013 | isbn=978-1-4816-8886-4 | url=https://books.google.com/books?id=JNHWK64_bHYC&pg=PA866 | access-date=26 October 2018 | page=866}} It thus terminates immunoglobulin and B-cell receptor (BCR) expression in B-lymphocytes and results in B-cell death since survival of such cells requires BCR expression. This process is initiated by the enzyme activation-induced deaminase upon B-cell activation. LSR is thus one of the pathways that can result into activation-induced cell death in the B-cell lineage.{{cite journal | last1=Peron | first1=S. | last2=Laffleur | first2=B. | last3=Denis-Lagache | first3=N. | last4=Cook-Moreau | first4=J. | last5=Tinguely | first5=A. | last6=Delpy | first6=L. | last7=Denizot | first7=Y. | last8=Pinaud | first8=E. | last9=Cogne | first9=M. | title=AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells | journal=Science | publisher=American Association for the Advancement of Science (AAAS) | volume=336 | issue=6083 | date=26 April 2012 | issn=0036-8075 | pmid=22539552 | doi=10.1126/science.1218692 | pages=931–934| bibcode=2012Sci...336..931P | s2cid=1513560 }}