mazaticol

{{Short description|Chemical compound}}

{{infobox drug

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = I6X824OGWZ

| verifiedrevid = 443480285

| IUPAC_name = [(1R,3R,5R)-6,6,9-trimethyl-9-azabicyclo[3.3.1]non-3-yl hydroxy(di-2-thienyl)acetate

| image = Mazaticol.svg

| width = 200

| CAS_number = 42024-98-6

| ATC_prefix = N04

| ATC_suffix = AA10

| PubChem = 68667

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| DrugBank =

| ChemSpiderID = 61921

| smiles = CC1(CC[C@@H]2C[C@H](C[C@H]1N2C)OC(=O)C(c3cccs3)(c4cccs4)O)C

| StdInChI = 1S/C21H27NO3S2/c1-20(2)9-8-14-12-15(13-16(20)22(14)3)25-19(23)21(24,17-6-4-10-26-17)18-7-5-11-27-18/h4-7,10-11,14-16,24H,8-9,12-13H2,1-3H3/t14-,15-,16-/m1/s1

| StdInChIKey = AMHPTVWBZSYFSS-BZUAXINKSA-N

| C=21|H=27|N=1|O=3|S=2

| bioavailability =

| protein_bound =

| metabolism =

| elimination_half-life =

| excretion =

| pregnancy_category=

| legal_status = Uncontrolled

| routes_of_administration = Oral

}}

Mazaticol (Pentona) is an anticholinergic used as an antiparkinsonian agent in Japan.

The compound was known as PG-501 is first mentioned in Japanese studies in the early 1970s, noting "PG-501 was found to have pronounced anti-acetylcholine, anti-tremorine-induced tremor, anti-physostigmine-induced death, anti-haloperidol-induced parkinsonism and anti EEG arousal activities."{{cite journal | vauthors = Nose T, Kojima M, Ishida R, Shintomi K, Kowa Y | title = [Pharmacological properties of 6,6,9-trimethyl-9-azabicyclo (3,3,1)non-3 beta-yl-alpha, alpha-di(2-thienyl) glycolate hydrochloride monohydrate (PG-501), a new anti-parkinsonian agent] | language = Japanese | journal = Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica | volume = 67 | issue = 4 | pages = 387–405 | date = July 1971 | pmid = 5000167 | doi = 10.1254/fpj.67.387 | doi-access = free }}{{cite journal | vauthors = Kosaka K |date=1971 |title=パ ー キ ン ソ ン病 に対 す るPG-501の 使 用 経 験/The Beneficial Effect of PG-501 on Parkinsonism |url=https://www.jstage.jst.go.jp/article/jscpt1970/2/3/2_3_230/_article/-char/en |journal= Rinsho Yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics|volume=2 |issue=3 |pages=230–235 |doi=10.3999/jscpt.2.230 |access-date=December 18, 2023|doi-access=free }}