medronic acid

{{chembox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 476996867

| ImageFile = Medronic acid.png

| ImageSize = 150px

| PIN = Methylenebis(phosphonic acid)

| OtherNames = methanediphosphonic acid; methylene diphosphonate; medronate; phosphonomethylphosphonic acid; MDP

|Section1={{Chembox Identifiers

| UNII_Ref = {{fdacite|changed|FDA}}

| UNII = 73OS0QIN3O

| ChEBI_Ref = {{ebicite|changed|EBI}}

| ChEBI = 43945

| ChEMBL_Ref = {{ebicite|correct|EBI}}

| ChEMBL = 180570

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI =1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = MBKDYNNUVRNNRF-UHFFFAOYSA-N

| CASNo_Ref = {{cascite|changed|??}}

| CASNo = 1984-15-2

| PubChem = 16124

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 15308

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = D04887

| SMILES = O=P(O)(O)CP(=O)(O)O

}}

|Section2={{Chembox Properties

| C=1 | H=6 | O=6 | P=2

| Appearance =

| Density =

| MeltingPtC = 199 to 200

| MeltingPt_ref = {{Merck12th}}

| BoilingPt =

| Solubility =

}}

|Section3={{Chembox Hazards

| MainHazards =

| FlashPt =

| AutoignitionPt =

| LD50 = 45-50 mg/kg (i.v., mice, rabbits)

}}

Medronic acid (conjugate base, medronate), also known as methylene diphosphonate, is the smallest bisphosphonate. Its complex with radioactive technetium, ^99mTc medronic acid, is used in nuclear medicine to detect bone abnormalities, including metastases.

References