methylamide

{{One source|date=November 2021}}

In biochemistry, an N-methylamide (NME) is a blocking group for the C-terminus end of peptides. When the carboxyl group of the C-terminus is replaced with a methylamide, further elongation of the peptide chain is prevented. C-Terminal modified peptides are also useful for the modulation of structure-activity relationships and for modifying conformational properties of peptides. N-Methylamides can be prepared directly from solid phase resin-bound peptides.{{cite journal |author1=Ajayaghosh, A. |author2=Pillai, V. N. Rajasekharan | title = Photo-triggered selective C-terminal N-methylamidative cleavage of polyethylene glycol-bound peptides | journal = Tetrahedron Letters | year = 1996 | volume = 37 | issue = 35 | pages = 6421–6424 | doi = 10.1016/0040-4039(96)01363-9}}