methylornithine synthase

{{Infobox enzyme

| Name = Methylornithine synthase

| EC_number = 5.4.99.58

| CAS_number =

| GO_code =

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Methylornithine synthase ({{EnzExplorer|5.4.99.58}}, PylB) is an enzyme with systematic name L-lysine carboxy-aminomethylmutase.{{cite journal | vauthors = Gaston MA, Zhang L, Green-Church KB, Krzycki JA | title = The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine | journal = Nature | volume = 471 | issue = 7340 | pages = 647–50 | date = March 2011 | pmid = 21455182 | pmc = 3070376 | doi = 10.1038/nature09918 | bibcode = 2011Natur.471..647G }}{{cite journal | vauthors = Quitterer F, List A, Eisenreich W, Bacher A, Groll M | title = Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis | journal = Angewandte Chemie | volume = 51 | issue = 6 | pages = 1339–42 | date = February 2012 | pmid = 22095926 | doi = 10.1002/anie.201106765 }} This enzyme catalyses the conversion of L-lysine into (3R)-3-methyl-D-ornithine.

The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical enzymes.