miRBase

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{{Infobox biodatabase

|title = miRBase

|logo = File:MiRBase logo.png

|description = microRNA database

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|center = University of Manchester

|laboratory =

|author = Ana Kozomara

|citation = Kozomara & al. (2011)

|released = 2010

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|url = {{URL|http://www.mirbase.org/}}

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In bioinformatics, miRBase is a biological database that acts as an archive of microRNA sequences and annotations.{{cite journal |last1=Kozomara |first1=A. |last2=Griffiths-Jones |first2=S. |title=MiRBase: integrating microRNA annotation and deep-sequencing data |journal=Nucleic Acids Research |volume=39 |issue=Database issue |pages=D152–7 |year=2010 |pmid=21037258 |pmc=3013655 |doi=10.1093/nar/gkq1027}}{{cite book |last1=Griffiths-Jones |first1=Sam |title=Current Protocols in Bioinformatics |volume=Chapter 12 |chapter=MiRBase: microRNA Sequences and Annotation |pages=Unit 12.9.1–10 |year=2010 |doi=10.1002/0471250953.bi1209s29|pmid=20205188 |isbn=978-0471250951 |s2cid=19303675 }}{{cite journal |last1=Griffiths-Jones |first1=S. |last2=Saini |first2=H. K. |last3=Van Dongen |first3=S. |last4=Enright |first4=A. J. |title=MiRBase: tools for microRNA genomics |journal=Nucleic Acids Research |volume=36 |issue=Database issue |pages=D154–8 |year=2007 |pmid=17991681 |pmc=2238936 |doi=10.1093/nar/gkm952}}{{cite book |last1=Griffiths-Jones |first1=Sam |title=MicroRNA Protocols |series=Methods in Molecular Biology |chapter=MiRBase: the MicroRNA Sequence Database |volume=342 |pages=129–38 |year=2006 |doi=10.1385/1-59745-123-1:129|pmid=16957372 |isbn=1-59745-123-1 }} As of September 2010 it contained information about 15,172 microRNAs. This number has risen to 38,589 by March 2018.{{Cite web|url=ftp://mirbase.org/pub/mirbase/CURRENT/README|archive-url=https://web.archive.org/web/20200612011109/ftp://mirbase.org/pub/mirbase/CURRENT/README|archive-date=2020-06-12|url-status=dead|title=Mirbase 22 Release Notes}} The miRBase registry provides a centralised system for assigning new names to microRNA genes.{{cite journal |last1=Griffiths-Jones |first1=S. |last2=Grocock |first2=RJ |last3=Van Dongen |first3=S |last4=Bateman |first4=A |last5=Enright |first5=AJ |title=MiRBase: microRNA sequences, targets and gene nomenclature |journal=Nucleic Acids Research |volume=34 |issue=Database issue |pages=D140–4 |year=2006 |pmid=16381832 |pmc=1347474 |doi=10.1093/nar/gkj112}}

miRBase grew from the microRNA registry resource set up by Sam Griffiths-Jones in 2003.{{cite journal |author=Griffiths-Jones S |title=The microRNA Registry |journal=Nucleic Acids Res. |volume=32 |issue=Database issue |pages=D109–11 |date=January 2004 |pmid=14681370 |pmc=308757 |doi=10.1093/nar/gkh023 }}

According to Ana Kozomara and Sam Griffiths-Jones miRBase has five aims:

1. To provide a consistent naming system for microRNAs
2. To provide a central place collecting all known microRNA sequences
3. To provide human and computer readable information for each microRNA
4. To provide primary evidence for each microRNA
5. To aggregate and link to microRNA target information

MiRBase contains miRNAs belonging of various species belonging to Alveolata, Chromalveolata, Metazoa, Mycetozoa, Viridiplantae and Viruses. For the Viridiplantae, in release 21 (2014) data is available for 73 species. This includes 4800 unique mature miRNAs and 8480 precursor sequences.{{Cite journal|last1=Nithin|first1=Chandran|last2=Thomas|first2=Amal|last3=Basak|first3=Jolly|last4=Bahadur|first4=Ranjit Prasad|date=2017-11-15|title=Genome-wide identification of miRNAs and lncRNAs in Cajanus cajan|journal=BMC Genomics|volume=18|issue=1|pages=878|doi=10.1186/s12864-017-4232-2|pmid=29141604|pmc=5688659|issn=1471-2164 |doi-access=free }}

The current version of MiRBase is release 22 (March 2018).