minzasolmin

{{Chembox

| IUPACName = N-[(2R)-1-(1H-indol-3-yl)hexan-2-yl]-2-(4-methylpiperazin-1-yl)-1,3-thiazole-5-carboxamide

| ImageFile = Minzasolmin.png

|Section1={{Chembox Identifiers

| CASNo = 1802518-92-8

| ChEMBL = 5095072

| ChemSpiderID = 115010423

| PubChem = 118279413

| UNII = 3N0435TG2D

| KEGG = D12796

| StdInChI=1S/C23H31N5OS/c1-3-4-7-18(14-17-15-24-20-9-6-5-8-19(17)20)26-22(29)21-16-25-23(30-21)28-12-10-27(2)11-13-28/h5-6,8-9,15-16,18,24H,3-4,7,10-14H2,1-2H3,(H,26,29)/t18-/m1/s1

| StdInChIKey = GDFWCSZNQVAQGR-GOSISDBHSA-N

| SMILES = CCCC[C@H](CC1=CNC2=CC=CC=C21)NC(=O)C3=CN=C(S3)N4CCN(CC4)C

}}

|Section2={{Chembox Properties

| C=23 | H=31 | N=5 | O=1 | S=1

}}

|Section8={{Chembox Related

}}

}}

Minzasolmin (development names DLX313 and UCB0599) is an experimental small-molecule drug in development for Parkinson's disease that is designed to prevent misfolding of α-synuclein.{{cite journal |last1=Schwarz |first1=Thomas C. |last2=Beier |first2=Andreas |last3=Ledolter |first3=Karin |last4=Gossenreiter |first4=Thomas |last5=Höfurthner |first5=Theresa |last6=Hartl |first6=Markus |last7=Baker |first7=Terry S. |last8=Taylor |first8=Richard J. |last9=Konrat |first9=Robert |title=High-resolution structural information of membrane-bound α-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599 |journal=Proceedings of the National Academy of Sciences |date=11 April 2023 |volume=120 |issue=15 |pages=e2201910120 |doi=10.1073/pnas.2201910120|pmid=37027427 |pmc=10104497 |bibcode=2023PNAS..12001910S |s2cid=258007748 }}{{cite journal |last1=Price |first1=Diana L. |last2=Khan |first2=Asma |last3=Angers |first3=Rachel |last4=Cardenas |first4=Alvaro |last5=Prato |first5=Maria Key |last6=Bani |first6=Massimo |last7=Bonhaus |first7=Douglas W. |last8=Citron |first8=Martin |last9=Biere |first9=Anja-Leona |title=In vivo effects of the alpha-synuclein misfolding inhibitor minzasolmin supports clinical development in Parkinson's disease |journal=npj Parkinson's Disease |date=17 July 2023 |volume=9 |issue=1 |page=114 |doi=10.1038/s41531-023-00552-7 |pmid=37460603 |pmc=10352257 |language=en |issn=2373-8057}}