mir-166 microRNA precursor

{{Infobox rfam

| Name = mir-166 microRNA precursor

| image = RF00075.jpg

| width =

| caption = Predicted secondary structure and sequence conservation of mir-166

| Symbol = mir-166

| AltSymbols =

| Rfam = RF00075

| miRBase =MI0000201

| miRBase_family = MIPF0000004

| RNA_type = Gene; miRNA

| Tax_domain = Eukaryota

| GO = {{GO|0035195}} {{GO|0035068}}

| SO = {{SO|0001244}}

| CAS_number =

| EntrezGene =

| HGNCid =

| OMIM =

| PDB =

| RefSeq =

| Chromosome =

| Arm =

| Band =

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}}

The plant mir-166 microRNA precursor is a small non-coding RNA gene. This microRNA (miRNA) has now been predicted or experimentally confirmed in a wide range of plant species.{{cite web|title=miRNA gene family: MIR166|url=http://www.mirbase.org/cgi-bin/mirna_summary.pl?fam=MIPF0000004|work=mirBASE|publisher=University of Manchester|access-date=5 September 2011}} microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product.{{cite journal | vauthors = Ambros V | title = microRNAs: tiny regulators with great potential | journal = Cell | volume = 107 | issue = 7 | pages = 823–6 | date = December 2001 | pmid = 11779458 | doi = 10.1016/S0092-8674(01)00616-X | doi-access = free }} In this case the mature sequence comes from the 3' arm of the precursor, and both Arabidopsis thaliana and rice genomes contain a number of related miRNA precursors which give rise to almost identical mature sequences.{{cite journal | vauthors = Reinhart BJ, Weinstein EG, Rhoades MW, Bartel B, Bartel DP | title = MicroRNAs in plants | journal = Genes & Development | volume = 16 | issue = 13 | pages = 1616–26 | date = July 2002 | pmid = 12101121 | pmc = 186362 | doi = 10.1101/gad.1004402 }} The mature products are thought to have regulatory roles through complementarity to messenger RNA.