mir-30 microRNA precursor

{{Short description|Precursor microRNA family}}

{{Infobox rfam

| Name = mir-30 microRNA precursor

| image = RF00131.jpg

| width =

| caption = Predicted secondary structure and sequence conservation of mir-30

| Symbol = mir-30

| AltSymbols =

| Rfam = RF00131

| miRBase = MI0000088

| miRBase_family = MIPF0000005

| RNA_type = Gene; miRNA

| Tax_domain = Eukaryota

| GO = {{GO|0035068}} {{GO|0035195}}

| SO = {{SO|0001244}}

| CAS_number =

| EntrezGene =

| HGNCid =

| OMIM =

| PDB =

| RefSeq =

| Chromosome =

| Arm =

| Band =

| LocusSupplementaryData =

}}

miR-30 microRNA precursor is a small non-coding RNA that regulates gene expression. Animal microRNAs are transcribed as pri-miRNA (primary miRNA) of varying length which in turns are processed in the nucleus by Drosha into ~70 nucleotide stem-loop precursor called pre-miRNA (precursor miRNA) and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from both the 3' (miR-30){{cite journal | last = Lagos-Quintana | first = M |author2=Rauhut R |author3=Lendeckel W |author4=Tuschl T | year = 2001 | title = Identification of novel genes coding for small expressed RNAs | journal = Science | volume = 294 | pages = 853–858 | pmid = 11679670 | doi = 10.1126/science.1064921 | issue = 5543| bibcode = 2001Sci...294..853L | hdl = 11858/00-001M-0000-0012-F65F-2 | s2cid = 18101169 | hdl-access = free }} and 5' (mir-97-6){{cite journal | last = Mourelatos | first = Z |author2=Dostie J |author3=Paushkin S |author4=Sharma A |author5=Charroux B |author6=Abel L |author7=Rappsilber J |author7-link=Juri Rappsilber |author8=Mann M |author9=Dreyfuss G | year = 2002 | title = miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs | journal = Genes Dev | volume = 16 | pages = 720–728 | pmid = 11914277 | doi = 10.1101/gad.974702 | issue = 6 | pmc = 155365}} arms of the precursor. The products are thought to have regulatory roles through complementarity to mRNA.{{cite journal |author=Ambros V |title=microRNAs: tiny regulators with great potential |journal=Cell |volume=107 |issue=7 |pages=823–6 |year=2001 |pmid=11779458 |doi=10.1016/S0092-8674(01)00616-X|doi-access=free }}

A screen of 17 miRNAs that have been predicted to regulate a number of breast cancer associated genes found variations in the microRNAs

miR-17 and miR-30c-1, these patients were noncarriers of BRCA1 or BRCA2 mutations, lending the possibility that familial breast cancer may be caused by variation in these miRNAs.{{cite journal

|vauthors=Shen J, Ambrosone CB, Zhao H |title=Novel genetic variants in microRNA genes and familial breast cancer

|journal=Int J Cancer |volume=124 |issue=5 |pages=1178–82 |year=2009 |pmid=19048628 |doi=10.1002/ijc.24008|doi-access=free }}

Members of the miR-30 family have been found to be highly expressed in heart cells.{{cite journal |vauthors=Duisters RF, Tijsen AJ, Schroen B, etal |title=miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling |journal=Circ. Res. |volume=104 |issue=2 |pages=170–8, 6p following 178 |date=January 2009 |pmid=19096030 |doi=10.1161/CIRCRESAHA.108.182535 |doi-access= }}