mir-BART2 microRNA precursor family

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{{Infobox rfam

| Name = mir-BART2 microRNA precursor family

| image = RF00364.jpg

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| caption = Predicted secondary structure and sequence conservation of mir-BART2

| Symbol = mir-BART2

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| Rfam = RF00364

| miRBase = MI0001068

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| RNA_type = Gene; miRNA

| Tax_domain = Viruses

| GO = {{GO|0035195}} {{GO|0035068}}

| SO = {{SO|0001244}}

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}}

The mir-BART2 microRNA precursor found in Human herpesvirus 4 (Epstein–Barr virus) and Cercopithicine herpesvirus 15. mir-BART2 is expressed in all stages of infection but expression is significantly elevated in the lytic stage. In Epstein-Barr virus, mir-BART2 is found in the intronic regions of the BART (Bam HI-A region rightward transcript) gene whose function is unknown. mir-BART2 is thought to target the virally encoded DNA polymerase BALF5 for degradation. The mature sequence is excised from the 5' arm of the hairpin.{{cite journal | vauthors = Pfeffer S, Zavolan M, Grässer FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T | title = Identification of virus-encoded microRNAs | journal = Science | volume = 304 | issue = 5671 | pages = 734–6 | date = April 2004 | pmid = 15118162 | doi = 10.1126/science.1096781 | s2cid = 25287167 }}