mitosene
{{Short description|Class of organic chemicals}}
{{confused|mitosan}}
The mitosenes are a class of organic chemicals based on a quinone-containing three-ring structure related to the two-ring core of the indolequinones. They are derived from the mitomycins by reduction and are the active alkylating agents responsible for the antitumor activity of the mitomycins.{{cite journal |title= Mitosene–DNA Adducts. Characterization of Two Major DNA Monoadducts Formed by 1,10-Bis(acetoxy)-7-methoxymitosene upon Reductive Activation |last1= Maliepaard |first1= Marc |last2= de Mol |first2= Nico J. |last3= Tomasz |first3= Maria |last4= Gargiulo |first4= Dario |last5= Janssen |first5= Lambert H. M. |last6= van Duynhoven |first6= John P. M. |last7= van Velzen |first7= Ewoud J. J. |last8= Verboom |first8= Willem |last9= Reinhoudt |first9= David N. |journal= Biochemistry |year= 1997 |volume= 36 |issue= 30 |pages= 9211–9220 |doi= 10.1021/bi9700680 |pmid=9230054|url= https://research.utwente.nl/en/publications/mitosenedna-adducts-characterization-of-two-major-dna-monoadducts-formed-by-110bisacetoxy7methoxymitosene-upon-reductive-activation(32388144-99c3-43e4-9da3-b66abbd3df60).html }}{{cite journal |title= A comparison of mechanisms proposed for the conversion of mitomycins into mitosenes |first=1 Bhashyam S. |last1= Iyengar |first2= William A. |last2= Remers |journal= J. Med. Chem. |year= 1985 |volume= 28 |issue= 7 |pages= 963–967 |doi= 10.1021/jm00145a021 |pmid=3925148 }}