monolysocardiolipin

File:Monolysocardiolipin.svg

Monolysocardiolipin (MLCL) is a phospholipid with three fatty acid chains located in the inner membrane of mitochondria.

MLCL is normally present as part of the metabolic cycle of mitochondrial lipids, such as cardiolipin.{{cite journal|vauthors=Ma BJ, Taylor WA, Dolinsky VW, Hatch GM | title=Acylation of monolysocardiolipin in rat heart. | journal=J Lipid Res | year= 1999 | volume= 40 | issue= 10 | pages= 1837–45 | doi=10.1016/S0022-2275(20)34900-2 | pmid=10508203 | doi-access=free }} It is remodeled by the enzymes monolysocardiolipin acyltransferase, lysocardiolipin acyltransferase, and tafazzin, which transfer a fourth fatty acid chain onto the phospholipid.{{cite journal|last1=Taylor|first1=W. A.|last2=Hatch|first2=G. M.|title=Identification of the Human Mitochondrial Linoleoyl-coenzyme A Monolysocardiolipin Acyltransferase (MLCL AT-1)|journal=Journal of Biological Chemistry|volume=284|issue=44|year=2009|pages=30360–30371|issn=0021-9258|doi=10.1074/jbc.M109.048322|pmid=19737925|pmc=2781591|doi-access=free}}

References

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{{Phospholipids}}

Category:Phospholipids

Category:Membrane biology

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