mucin 5AC

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{{Short description|Protein-coding gene in the species Homo sapiens}}

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Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans.{{cite journal |vauthors=Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N | title = Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes? | journal = Biochem J | volume = 305 | issue = Pt 1| pages = 211–9 |date=Feb 1995 | pmid = 7826332 | pmc = 1136451 | doi = 10.1042/bj3050211}}{{cite journal |vauthors=van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW | title = Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif | journal = Biochem Biophys Res Commun | volume = 245 | issue = 3 | pages = 853–9 |date=Jun 1998 | pmid = 9588204 | doi = 10.1006/bbrc.1998.8535 }}{{cite web | title = Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&dopt=default&list_uids=4586&rn=1}}

MUC-5AC is a large gel-forming glycoprotein. In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance. Overproduction of MUC-5AC can contribute to diseases such as asthma and chronic obstructive pulmonary disease,{{cite journal | vauthors = Samsuzzaman M, Uddin MS, Shah MA, Mathew B | title = Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production | journal = Life Sciences | volume = 231 | issue = | pages = 116485 | date = August 2019 | pmid = 31116959 | doi = 10.1016/j.lfs.2019.05.041 | s2cid = 162182150 }} and has also been associated with greater protection against influenza infection.{{Cite journal|last1=Ehre|first1=Camille|last2=Worthington|first2=Erin N.|last3=Liesman|first3=Rachael M.|last4=Grubb|first4=Barbara R.|last5=Barbier|first5=Diane|last6=O'Neal|first6=Wanda K.|last7=Sallenave|first7=Jean-Michel|last8=Pickles|first8=Raymond J.|last9=Boucher|first9=Richard C.|date=2012-10-09|title=Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=109|issue=41|pages=16528–16533|doi=10.1073/pnas.1206552109|issn=1091-6490|pmc=3478656|pmid=23012413|bibcode=2012PNAS..10916528E |doi-access=free}}