multiple sclerosis functional composite

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The Multiple Sclerosis Functional Composite (MSFC) is a clinical trial outcome measure of assessing the severity of multiple sclerosis primarily used in research.{{cite journal | vauthors = Rudick RA, Cutter G, Reingold S | s2cid = 31529508 | title = The multiple sclerosis functional composite: a new clinical outcome measure for multiple sderosis trials | journal = Multiple Sclerosis | volume = 8 | issue = 5 | pages = 359–65 | date = October 2002 | pmid = 12356200 | doi = 10.1191/1352458502ms845oa }} The score is based on a combination of timed tests of walking, arm function, and cognitive ability. It was developed over two years from 1994 to 1996 by the National Multiple Sclerosis Society.{{cite journal | vauthors = Balcer LJ, Baier ML, Cohen JA, Kooijmans MF, Sandrock AW, Nano-Schiavi ML, Pfohl DC, Mills M, Bowen J, Ford C, Heidenreich FR, Jacobs DA, Markowitz CE, Stuart WH, Ying GS, Galetta SL, Maguire MG, Cutter GR | s2cid = 17583827 | display-authors = 6 | title = Contrast letter acuity as a visual component for the Multiple Sclerosis Functional Composite | journal = Neurology | volume = 61 | issue = 10 | pages = 1367–73 | date = November 2003 | pmid = 14638957 | doi = 10.1212/01.WNL.0000094315.19931.90 | url = https://n.neurology.org/content/61/10/1367 | url-access = subscription }}

MSFC was developed to improve the standard measure of MS disability for clinical trials and to create a multidimensional metric of overall MS clinical status. The evaluation includes a three-part performance scale:

• Timed 25-Foot Walk (T25FT) - assessment of leg function by moving a short walking distance
• 9-Hole Peg Test (9HPT) - assessment of arm function using breadboard test
• Paced Auditory Serial Addition test (PASAT) - attention/concentration test to assess cognitive functions

An integrated MSFC score is calculated using z-scores.{{cite journal | vauthors = Meyer-Moock S, Feng YS, Maeurer M, Dippel FW, Kohlmann T | title = Systematic literature review and validity evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in patients with multiple sclerosis | journal = BMC Neurology | volume = 14 | issue = 1 | pages = 58 | date = March 2014 | pmid = 24666846 | pmc = 3986942 | doi = 10.1186/1471-2377-14-58 | doi-access = free }}