naive B cell

{{short description|B cell not yet exposed to an antigen}}

File:B_cell_activation_naive_to_plasma_cell.png

In immunology, a naive B cell is a B cell that has not been exposed to an antigen. These are located in the tonsils, spleen, and primary lymphoid follicles in lymph nodes.

Once exposed to an antigen, the naive B cell either becomes a memory B cell or a plasma cell that secretes antibodies specific to the antigen that was originally bound. Plasma cells do not last long in the circulation; this is in contrast to memory cells that last for very long periods of time. Memory cells do not secrete antibodies until activated by their specific antigen.

{{cite journal |vauthors=Airoldi I, Raffaghello L, Cocco C, etal |title=Heterogeneous expression of interleukin-18 and its receptor in B-cell lymphoproliferative disorders deriving from naive, germinal center, and memory B lymphocytes |journal=Clin. Cancer Res. |volume=10 |issue=1 Pt 1 |pages=144–54 |date=January 2004 |pmid=14734463 |doi=10.1158/1078-0432.CCR-1026-3 |s2cid=1413735 |url=http://clincancerres.aacrjournals.org/content/10/1/144.full |doi-access= }}{{cite journal |author=Lang ML |title=How do natural killer T cells help B cells? |journal=Expert Rev Vaccines |volume=8 |issue=8 |pages=1109–21 |date=Aug 2009 |pmid=19627191 |pmc=2747240 |doi=10.1586/erv.09.56 }}

Naive B cells play a key role in predicting humoral responses to COVID-19 mRNA vaccines in immunocompromised patients, specifically measuring naive B cell levels could help predict and improve vaccination outcomes.{{cite journal | last=Schulz | first=Eduard | last2=Hodl | first2=Isabel | last3=Forstner | first3=Patrick | last4=Hatzl | first4=Stefan | last5=Sareban | first5=Nazanin | last6=Moritz | first6=Martina | last7=Fessler | first7=Johannes | last8=Dreo | first8=Barbara | last9=Uhl | first9=Barbara | last10=Url | first10=Claudia | last11=Grisold | first11=Andrea J. | last12=Khalil | first12=Michael | last13=Kleinhappl | first13=Barbara | last14=Enzinger | first14=Christian | last15=Stradner | first15=Martin H. | last16=Greinix | first16=Hildegard T. | last17=Schlenke | first17=Peter | last18=Steinmetz | first18=Ivo | title=CD19+IgD+CD27- Naïve B Cells as Predictors of Humoral Response to COVID 19 mRNA Vaccination in Immunocompromised Patients | journal=Frontiers in Immunology | volume=12 | date=2021-12-07 | issn=1664-3224 | pmid=34950155 | pmc=8688243 | doi=10.3389/fimmu.2021.803742 | doi-access=free | page=|medrxiv=10.1101/2021.08.11.21261898

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