netrin 1

NTN1 has been shown to interact with Deleted in Colorectal Cancer,{{cite journal |last=Geisbrecht |first=Brian V |author2=Dowd Kimberly A |author3=Barfield Ronald W |author4=Longo Patti A |author5=Leahy Daniel J |date=Aug 2003 |title=Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin |journal=J. Biol. Chem. |volume=278 |issue=35 |pages=32561–8 |location = United States| issn = 0021-9258| pmid = 12810718 |doi = 10.1074/jbc.M302943200 |doi-access=free }} and components of the extracellular matrix and the tumor microenvironment.Kryza D, Wischhusen J, Richaud M, Hervieu M, Sidi Boumedine J, Delcros JG, Besse S, Baudier T, Laval PA, Breusa S, Boutault E, Clermidy H, Rama N, Ducarouge B, Devouassoux-Shisheboran M, Chezal JM, Giraudet AL, Walter T, Mehlen P, Sarrut D, Gibert B.From netrin-1-targeted SPECT/CT to internal radiotherapy for management of advanced solid tumors. EMBO Mol Med. 2023 Apr 11;15(4):e16732. doi: 10.15252/emmm.202216732. Epub 2023 Mar 6. PMID 36876343

During the development of the central nervous system, when the dorsal and ventral signaling is being established, the floor plate is an important site for crossing for groups of neural processes at the dorsal midline. Once crossed through the floor plate, these groups are now referred to as commissural axons. These neuronal cell bodies are signaled by Netrin 1 to be attracted to the floor plate from the dorsal half of the neural tube. NTN1 is a gene that encodes for the protein, Netrin-1. In a study done in knockout mice with a depletion of floor plate Netrin-1, it was shown that corticospinal axon tract midline crossing was disrupted.{{cite journal |last1=Pourchet |first1=Oriane |title=Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements |journal=Cell Reports |date=Jan 19, 2021 |volume=34 |issue=3 |page=108654 |doi=10.1016/j.celrep.2020.108654 |pmid=33472083|s2cid=231663364 |hdl=10261/308989 |hdl-access=free }} This study was done to show characteristics of patients with human congenital mirror movement disorder.

Afterwards, proper positioning of axons and midline crossing are pioneered by the Slit-Robo system where Slit proteins act as axonal repellents and Robo proteins (Robo-1, Robo-2, Robo-3) act in conjunction with Slit ligands to be their receptors.{{cite journal |last1=Blockus |first1=Heike |last2=Chedotal |first2=Alain |title=Slit-Robo signaling |journal=Development |date=Sep 1, 2016 |volume=143 |issue=17 |pages=3037–3044 |doi=10.1242/dev.132829 |pmid=27578174|s2cid=10315151 |doi-access=free }} Slit with Robo-1 and Robo-2 repel axonal extension at the midline thereby commissural axons expressing Robo-3 cross the midline by interfering with Slit/Robo-1, Robo-2 repulsive activity. After crossing the floor plate, Robo-3 is downregulated and Slit/Robo-1, Robo-2 continue to express their repulsiveness at the midline. Furthermore, mutations in Robo-3 cause horizontal gaze palsy with progressive scoliosis.

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• {{cite journal | vauthors = Bouhidel JO, Wang P, Siu KL, Li H, Youn JY, Cai H | title = Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy | journal = Biochim. Biophys. Acta | volume = 1852 | issue = 2 | pages = 277–89 | date = February 2015 | pmid = 24928309 | pmc = 4262720 | doi = 10.1016/j.bbadis.2014.06.005 }}
• {{Cite journal | author=Arakawa H |title=Netrin-1 and its receptors in tumorigenesis. |journal=Nat. Rev. Cancer |volume=4 |issue= 12 |pages= 978–87 |year= 2005 |pmid= 15573119 |doi= 10.1038/nrc1504 |s2cid=867903 }}
• {{Cite journal |vauthors=Mehlen P, Furne C |title=Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis. |journal=Cell. Mol. Life Sci. |volume=62 |issue= 22 |pages= 2599–616 |year= 2006 |pmid= 16158190 |doi= 10.1007/s00018-005-5191-3 |s2cid=29781275 |pmc=11139161 }}
• {{Cite journal |vauthors=Keino-Masu K, Masu M, Hinck L, etal |title=Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. |journal=Cell |volume=87 |issue= 2 |pages= 175–85 |year= 1996 |pmid= 8861902 |doi=10.1016/S0092-8674(00)81336-7 |s2cid=18468998 |doi-access=free }}
• {{Cite journal |vauthors=Serafini T, Colamarino SA, Leonardo ED, etal |title=Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. |journal=Cell |volume=87 |issue= 6 |pages= 1001–14 |year= 1997 |pmid= 8978605 |doi=10.1016/S0092-8674(00)81795-X |s2cid=1008380 |doi-access=free }}
• {{Cite journal |vauthors=Togari A, Mogi M, Arai M, etal |title=Expression of mRNA for axon guidance molecules, such as semaphorin-III, netrins and neurotrophins, in human osteoblasts and osteoclasts. |journal=Brain Res. |volume=878 |issue= 1–2 |pages= 204–9 |year= 2001 |pmid= 10996153 |doi=10.1016/S0006-8993(00)02700-1 |s2cid=28322080 }}
• {{Cite journal |vauthors=Corset V, Nguyen-Ba-Charvet KT, Forcet C, etal |title=Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor |journal=Nature |volume=407 |issue= 6805 |pages= 747–50 |year= 2000 |pmid= 11048721 |doi= 10.1038/35037600 |bibcode=2000Natur.407..747C |s2cid=4423128 }}
• {{Cite journal |vauthors=Manitt C, Colicos MA, Thompson KM, etal |title=Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cord |journal=J. Neurosci. |volume=21 |issue= 11 |pages= 3911–22 |year= 2001 |pmid= 11356879 |doi= 10.1523/JNEUROSCI.21-11-03911.2001|pmc= 6762706 }}
• {{Cite journal |vauthors=Srinivasan K, Strickland P, Valdes A, etal |title=Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis |journal=Dev. Cell |volume=4 |issue= 3 |pages= 371–82 |year= 2003 |pmid= 12636918 |doi=10.1016/S1534-5807(03)00054-6 |doi-access=free }}
• {{Cite journal |vauthors=Yebra M, Montgomery AM, Diaferia GR, etal |title=Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration |journal=Dev. Cell |volume=5 |issue= 5 |pages= 695–707 |year= 2003 |pmid= 14602071 |doi=10.1016/S1534-5807(03)00330-7 |doi-access=free }}
• {{Cite journal |vauthors=Mazelin L, Bernet A, Bonod-Bidaud C, etal |title=Netrin-1 controls colorectal tumorigenesis by regulating apoptosis |journal=Nature |volume=431 |issue= 7004 |pages= 80–4 |year= 2004 |pmid= 15343335 |doi= 10.1038/nature02788 |bibcode=2004Natur.431...80M |s2cid=4417992 }}
• {{Cite journal |vauthors=Kato HD, Kondoh H, Inoue T, etal |title=Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis |journal=Gynecol. Oncol. |volume=95 |issue= 2 |pages= 281–9 |year= 2004 |pmid= 15491747 |doi= 10.1016/j.ygyno.2004.07.050 }}
• {{Cite journal |vauthors=Kruger RP, Lee J, Li W, Guan KL |title=Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation |journal=J. Neurosci. |volume=24 |issue= 48 |pages= 10826–34 |year= 2005 |pmid= 15574733 |doi= 10.1523/JNEUROSCI.3715-04.2004 |pmc=6730211 |doi-access= free }}
• {{Cite journal |vauthors=Hérincs Z, Corset V, Cahuzac N, etal |title=DCC association with lipid rafts is required for netrin-1-mediated axon guidance |journal=J. Cell Sci. |volume=118 |issue= Pt 8 |pages= 1687–92 |year= 2005 |pmid= 15811950 |doi= 10.1242/jcs.02296 |doi-access= free }}
• {{Cite journal |vauthors=Kim TH, Lee HK, Seo IA, etal |title=Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron |journal=J. Neurochem. |volume=95 |issue= 1 |pages= 1–8 |year= 2005 |pmid= 16181408 |doi= 10.1111/j.1471-4159.2005.03314.x | pmc=2683579 }}
• {{Cite journal |vauthors=Ly NP, Komatsuzaki K, Fraser IP, etal |title=Netrin-1 inhibits leukocyte migration in vitro and in vivo |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 41 |pages= 14729–34 |year= 2006 |pmid= 16203981 |doi= 10.1073/pnas.0506233102 | pmc=1253572 |bibcode=2005PNAS..10214729L |doi-access=free }}
• {{Cite journal |vauthors=Varadarajan, SG, Kong JH, Phan KD, Kao TJ, Panaitof SC, Cardin J, Eltzschig H, Kania A, Novitch BG, Butler SJ |title=Netrin1 produced by neural progenitors, not floor plate cells, is required for axon guidance in the spinal cord |journal=Neuron |volume=94 |issue= 4 |pages= 790-799 |year= 2017 |doi= 10.1016/j.neuron.2017.03.007 |pmid=28434801|doi-access=free |pmc=5576449 }}

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• {{UCSC genome browser|NTN1}}
• {{UCSC gene details|NTN1}}

Category:Netrins

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