neuronal calcium sensor

Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc.{{cite journal | author = Burgoyne RD| title = Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling| journal = Nat. Rev. Neurosci. | volume = 8 | issue = 3 |pages = 182–193 | year = 2007 | pmid = 17311005 | pmc = 1887812 | doi = 10.1038/nrn2093 }} All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.{{cite journal |vauthors=Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV | title = Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function | journal = Trends Neurosci. | volume = 27 | issue = 4 | pages = 203–9 | year = 2004 | pmid = 15046879 | doi = 10.1016/j.tins.2004.01.010 | s2cid = 24156457 }}

Members of NCS family

Highly evolutionarily conserved {{cite journal |vauthors=Weiss JL, Hui H, Burgoyne RD | title = Neuronal calcium sensor-1 regulation of calcium channels, secretion, and neuronal outgrowth | journal = Cell. Mol. Neurobiol. | volume = 30 | issue = 8 | pages = 1283–92 | year = 2010 | pmid = 21104311 | doi=10.1007/s10571-010-9588-7| s2cid = 2270302 | pmc = 11498851 }}
NCS1 (Frequenin){{cite journal |last1=Tsvetkov |first1=PO |last2=Roman |first2=AY |last3=Baksheeva |first3=VE |last4=Nazipova |first4=AA |last5=Shevelyova |first5=MP |last6=Vladimirov |first6=VI |last7=Buyanova |first7=MF |last8=Zinchenko |first8=DV |last9=Zamyatnin AA |first9=Jr |last10=Devred |first10=F |last11=Golovin |first11=AV |last12=Permyakov |first12=SE |last13=Zernii |first13=EY |title=Functional Status of Neuronal Calcium Sensor-1 Is Modulated by Zinc Binding. |journal=Frontiers in Molecular Neuroscience |date=2018 |volume=11 |pages=459 |doi=10.3389/fnmol.2018.00459 |pmid=30618610 |pmc=6302015|doi-access=free }}
VILIP-1 (Visinin-like-protein-1)
HPCAL4 (Visinin-like-protein-2)
HPCAL1 (Visinin-like-protein-3)
hippocalcin
neurocalcin
recoverin
Guanylate cyclase activator proteins (GCAPs)
Potassium Channel interacting proteins (KChIPs 1–4), including:

KCNIP1,

KCNIP2,

Calsenilin or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein),

KCNIP4

References

External links

{{MeshName|Neuronal+Calcium-Sensor+Proteins}}
[http://www.liv.ac.uk/physiology/ncs/index.html NCS proteins]

Category:Protein families