nolatrexed
{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 444208861
| ImageFile= nolatrexed.png
| ImageSize=200px
| PIN = 2-Amino-6-methyl-5-[(pyridin-4-yl)sulfanyl]quinazolin-4(1H)-one
| OtherNames=
|Section1={{Chembox Identifiers
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = K75ZUN743Q
| CASNo_Ref = {{cascite|correct|??}}
| CASNo=147149-76-6
| PubChem=108189
| SMILES=CC1=C(C2=C(C=C1)NC(=NC2=O)N)SC3=CC=NC=C3
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 97268
| InChI = 1/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19)
| InChIKey = XHWRWCSCBDLOLM-UHFFFAOYAK
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19)
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = XHWRWCSCBDLOLM-UHFFFAOYSA-N
}}
|Section2={{Chembox Properties
| Formula=C14H12N4OS
| MolarMass=284.34 g/mol
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
}}
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
}}
}}
Nolatrexed is a thymidylate synthase inhibitor.{{cite journal |vauthors=Hughes AN, Rafi I, Griffin MJ, etal |title=Phase I studies with the nonclassical antifolate nolatrexed dihydrochloride (AG337, THYMITAQ) administered orally for 5 days |journal=Clin. Cancer Res. |volume=5 |issue=1 |pages=111–8 |date=January 1999 |pmid=9918208 |url=http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9918208}}{{cite web|title=Nolatrexed|url=https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=108188|website=PubChem.gov|publisher=Pub Chem|access-date=12 August 2014}}