octreotate

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| SMILES = C[C@@H](O)[C@H](NC (=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(=O)O

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| PubChem = 71308309

| InChI = 1S/C49H64N10O11S2/c1-27(60)40-48(68)57-39(47(67)59-41(28(2)61)49(69)70)26-72-71-25-38(56-42(62)33(51)21-29-13-5-3-6-14-29)46(66)54-36(22-30-15-7-4-8-16-30)44(64)55-37(23-31-24-52-34-18-10-9-17-32(31)34)45(65)53-35(43(63)58-40)19-11-12-20-50/h3-10,13-18,24,27-28,33,35-41,52,60-61H,11-12,19-23,25-26,50-51H2,1-2H3,(H,53,65)(H,54,66)(H,55,64)(H,56,62)(H,57,68)(H,58,63)(H,59,67)(H,69,70)/t27-,28-,33-,35+,36+,37-,38+,39+,40+,41+/m1/s1

| InChIKey = KEKAEHDXIJNAIJ-WNIOSIORSA-N

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| Section2 = {{Chembox Properties

| C=49 | H=64 | N=10 | O=11 | S=2

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Octreotate or octreotide acid is a somatostatin analogue that is closely related to octreotide. Its amino acid sequence is

H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-OH

while octreotide has the terminal threonine reduced to the corresponding amino alcohol.

See also

References

  • {{Cite journal

| last1 = Laznicek | first1 = M.

| last2 = Laznickova | first2 = A.

| last3 = Mäcke | first3 = H. R.

| last4 = Eisenwiener | first4 = K.

| last5 = Reubi | first5 = J. C.

| last6 = Wenger | first6 = S.

| doi = 10.1089/108497802760804754

| title = Octreotide and Octreotate Derivatives Radiolabeled with Yttrium: Pharmacokinetics in Rats

| journal = Cancer Biotherapy & Radiopharmaceuticals

| volume = 17

| issue = 5

| pages = 527–533

| year = 2002

| pmid = 12470422

| pmc =

}}

{{GH/IGF-1 axis signaling modulators}}

Category:Cyclic peptides

Category:Somatostatin inhibitors

Category:Sulfur heterocycles

Category:Octapeptides

{{systemic-hormonal-drug-stub}}