omega-Atracotoxin
{{Short description|Insect-specific neurotoxin}}
{{DISPLAYTITLE:omega-Atracotoxin}}
{{Pfam_box
| Symbol = Omega-toxin
| Name = ω-Atracotoxin
| image =
| width =
| caption =
| Pfam= PF06357
| InterPro= IPR009415
| SMART=
| Prosite =
| SCOP = 1hvw
| TCDB =
| OPM family=
| OPM protein=
| PDB=
{{PDB3|1hvw}}A:4-23 {{PDB3|1axh}} :1-37
}}
omega-Atracotoxin (ω-atracotoxin) is an insect-specific neurotoxin produced by the Blue Mountains funnel-web spider. Its phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal amino acid residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels.{{cite journal |vauthors=King GF, Fletcher JI, Tedford HW |title=Functional significance of the beta hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a |journal=J. Biol. Chem. |volume=276 |issue=28 |pages=26568–26576 |year=2001 |pmid=11313356 |doi=10.1074/jbc.M102199200|doi-access=free }}
See also
References
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{{InterPro content|IPR009415}}
{{DEFAULTSORT:Atracotoxin, omega-}}
{{protein-stub}}
{{Neurotoxin-stub}}